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11-10-2013, 09:49 AM | #1 | ||
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Magnate
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can't vouch for researchers and no idea how dangerous this process is but interesting
http://www.mdscongress2013.org/pdf/l...-abstracts.pdf buried in .pdf LBA-32 An open label, single arm study on the effects of H. Pylori eradication in Parkinson’s disease Hasriza H 1 , Hamizah R 1 , Wan Nur Nafisah WY 1 , Tan HJ, 1 Rizal AM 2 , Lim SY, 3 Norlinah MI 1 1 Neurology Unit, Department of Medicine, UKM Medical Center, Kuala Lumpur 2 Department of Community Health, UKM Medical Center, Kuala Lumpur 3 Neurology Division, Department of Medicine, Un iversiti Malaya Medical Center, Kuala Lumpur Background: Previous studies have dem onstrated a higher prevalence of H. pylori infection in patients with Parkinsons disease (PD) compared to controls. H.pylori infection affects levodopa absorption and its eradication significantly improves clinical response to levodopa. Here, we studied the prevalence of H pylori infection, and its eradication effects among our PD patients. Methods: A prospective study involving idi opathic PD patients on levodopa therapy. 13 C-urea breath test (UBT) was used to detect H.pylori . UBT positive patients were given standard eradication therapy, and followed up at 6 and 12 weeks. Repeat UBT was pe rformed at 12 weeks. The UPDRS, PD NMSQ and PDQ39 were administered at baseline and post-er adicaton (6 and 12 weeks). Levodopa ‘onset’ time and ON duration were recorded. Results: Of 82 patients recruited, 27 (32.9%) had positive UBT. H.pylori positive patients had significantly poorer total UPDRS (p=0.005) and PDQ39 (p<0.0001) scores compared to H.pylori negative patients. At 12 weeks post-eradica tion, there was a significant reduction in levodopa ‘onset’ time (p=0.023), and improvement in ‘ON’ duration (p=0.023). The total UPDRS sc ores (p<0.0001), scores for parts II (p<0.0001), III (p=0.001) a nd IV (p<0.009) were significantly better. The total PDQ39 scores (p<0.0001) and subdomains mobility (p=0.001), ADL (p<0.0001), stigma (p=0.047) and cognition (p=0.01) significantly improved. The PD NM SQ did not show significant improvement. Conclusions: H.pylori eradication in PD patients significant ly improves levodopa onset time, ON duration, motor and quality of life param eters. Screening and eradication of H.pylori should be recommended in all PD patients, particular those with erratic response to levodopa |
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11-10-2013, 11:24 AM | #2 | |||
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In Remembrance
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At one time I knew a great deal about HP. In fact, it was one of the reasons that I ended up on this forum. Bt that has been a long time back and the knowledge has grown over with weeds and leaves, so I will not try to be comprehensive here. But I will yammer on a little because this is one of the most interesting critters around. For example-
1) The last I heard, there is only one place it can live - in the human stomach and its lining. It is totally dependent on us. 2) It is the only creature that is able to live in that acid drenched environment. These first two points alone indicate the possibility of a special relationship, more symbiotic than parasitical, so be cautious. 3) It comes in several strains and some are quite deadly, but only if you kill them. What HP does is to incorporate toxins into its cell wall that are only released upon its death - a darned "poison pill" defence! 4) At its death its remains include waste which, if you are sensitized by earlier exposure as PWP seem to be, can trigger a reaction in your own immune system that can become a "runaway" problem which is itself often fatal. 5) So, if you nuke it with the increasingly unreliable antibiotic cocktail-of-the-day, you may succeed in killing off a lifeform that you need for your own survival; you may succeed in killing part of the colony but just make the more dangerous survivors really angry so you end up fighting with a formerly possible ally who is now in full defense mode and you are standing in a pool of poisonous swill. Oh, and you killed off your other gut flora with that round of antibiotics as well. And those "Incredible Hulks" of your own immune system, the microglia, have gone into "T-Rex" mode and are rapidly getting out of control. Your doctor suggests more antibiotics (did I mention how fast this little muttha can mutate?), your fever is climbing, and you just don't feel very good... There are so many angles to H Pylori that it almost as if it were designed to teach Western medicine a little humility. There is a way that it should be possible to do this, although so far as I know no one has yet. Gien all the above, maybe we should look at it as an overgrowth of a needed part of our inner environment rather than an invader from outside. And instead of fighting a deadly eradication we could try to trim it back little by being clever ourselves. You see, HP burrows into our stomach wall but our stomach is constantly pushing the rude little fellows back out into the world, so to speak. The HP washes along with the gastric flow seeking to reattach to the wall before it is washed into the small intestine where it cannot survive. We need to be thinking in terms of disrupting things when HP is trying to reattach. This interference with the reproductive cycle triggers none of the negatives outlined. But how do we do it? It is surprisingly simple. Someone should go to PubMed and post it here, but there is a paper from research in India where they tested the suitability of two dozen or so plants for this purpose. I forget the runners up but the winner hands down was common parsley! You can buy it fresh or dried anywhere in the country. Quote:
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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