I am 76 year old diagnosed with tremor intensive Parkinson’s in 2001. Started on Sinemet Feb 2012. For the eight months I have had problems with Sinemet wearing off within two hours or not kicking in at all, 150 mg four times/d four hours apart. Started on Comtan two weeks ago, seems to almost make it to the next dose 70% of the time, but sometimes doesn’t kick in at all. I will need to give it more time, as it is am doing much better than before.

At around 2am I need to get out of bed but am very slow. I am not able to turn onto my side or back so I must get out of bed and get in again which I do three or four times. Each time is easier as I am moving better. By 7am I move and function just as well as on-time with meds at least until 1pm. So what I have been doing is starting my meds at 12 noon, 4pm, 8pm, and skipping the 8am dose.

My questions are….1. Why does my condition improve during the night?
2. Does it hurt to skip the 8am morning dose?
If I take the 8am dose and it does not kick-in then my morning is much worse than it would be by just skipping the dose. Any comments are appreciated.