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12-10-2013, 07:12 AM | #11 | ||
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If you read only one article about why 23 and me matters to Parkinson’s, read this one
Sergey Brin’s Search for a Parkinson’s Cure By Thomas Goetz June 22, 2010 | Wired Magazine July 2010 The full article is here: http://www.wired.com/magazine/2010/0...ys_search/all/ … in 2006, his wife-to-be, Anne Wojcicki, started the personal genetics company 23andMe (Google is an investor). As an alpha tester, Brin had the chance to get an early look at his genome... And there it was: He had the mutation. His mother’s 23andMe readout showed that she had it, too… .... he spent several months mulling over the results. He began to consult experts, starting with scientists at the Michael J. Fox Foundation and at the Parkinson’s Institute, which is not far from Google’s headquarters… ….His frustration is well founded. For decades, Parkinson’s research has been a poor cousin to the study of Alzheimer’s, which affects 10 times as many Americans and is therefore much more in the public eye. What is known about Parkinson’s has tended to emerge from observing patients in clinical practice, rather than from any sustained research… …And indeed, Brin has given money to both these areas of research, predominantly through gifts to the Parkinson’s Institute and to the Michael J. Fox Foundation, which is committed to what’s called translational research—getting therapies from researchers to the clinic as quickly as possible. Last February the Fox Foundation launched an international consortium of scientists working on LRRK2, with a mandate for collaboration, openness, and speed. “The goal is to get people to change their behavior and share information much more quickly and openly,” says Todd Sherer, head of the Fox Foundation’s research team. “We need to change the thinking.” As Brin’s understanding of Parkinson’s grew, though, and as he talked with Wojcicki about research models, he realized that there was an even bolder experiment in the offing… …Brin’s tolerance for “noisy data” is especially telling, since medical science tends to consider it poisonous. Biomedical researchers often limit their experiments to narrow questions that can be rigorously measured. …And by design it means the data almost never turn up insights beyond what the study set out to examine. …starting to wonder if that model could be inverted. Why not start with tons of data, a deluge of information, and then wade in, searching for patterns and correlations?... HERE ARE TWO TIMELINES: Here are two timelines—one from an esteemed traditional research project run by the NIH, the other from the 23andMe Parkinson’s Genetics Initiative. They reached almost the same conclusion about a possible association between Gaucher’s disease and Parkinson’s disease, but the 23andMe project took a fraction of the time.—Rachel Swaby Traditional Model • 1. Hypothesis: An early study suggests that patients with Gaucher’s disease (caused by a mutation to the GBA gene) might be at increased risk of Parkinson’s. • 2. Studies: Researchers conduct further studies, with varying statistical significance. • 3. Data aggregation: Sixteen centers pool information on more than 5,500 Parkinson’s patients. • 4. Analysis: A statistician crunches the numbers. • 5. Writing: A paper is drafted and approved by 64 authors. • 6. Submission: The paper is submitted to The New England Journal of Medicine. Peer review ensues. • 7. Acceptance: NEJM accepts the paper. • 8. Publication: The paper notes that people with Parkinson’s are 5.4 times more likely to carry the GBA mutation. • Total time elapsed: 6 years Parkinson’s Genetics initiative • 1. Tool Construction: Survey designers build the questionnaire that patients will use to report symptoms. • 2. Recruitment: The community is announced, with a goal of recruiting 10,000 subjects with Parkinson’s. • 3. Data aggregation: Community members get their DNA analyzed. They also fill out surveys. • 4. Analysis: Reacting to the NEJM paper, 23andMe researchers run a database query based on 3,200 subjects. The results are returned in 20 minutes. • 5. Presentation: The results are reported at a Royal Society of Medicine meeting in London: People with GBA are 5 times more likely to have Parkinson’s, which is squarely in line with the NEJM paper. The finding will possibly be published at a later date. • Total time elapsed: 8 months THIS IS WHAT THE PARKINSON EMPIRE STANDS TO LOSE. The idea that research that takes 6 years could be done in 8 months Did you just hear a dog whistle? |
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"Thanks for this!" says: | johnt (12-10-2013), lab rat (12-11-2013), lindylanka (12-11-2013), soccertese (12-10-2013), vlhperry (12-10-2013) |
12-10-2013, 11:16 AM | #12 | ||
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Just another day in American tort litigation.... |
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12-10-2013, 04:01 PM | #13 | |||
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Member aka Dianna Wood
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Vicky |
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12-10-2013, 07:53 PM | #14 | ||
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Senior Member
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The dog hears what we cannot hear;
the eagle sees what we cannot see the wolf circles around me an hour before sunrise. It is the Hour of the Wolf the hour when the guard falls asleep the hour when the most people are born the hour when the most people die can you hear the wolves singing "We were born to howl" If you should wander in the forest at night where every path deceives is that something coming up behind you? through the shadows of your worst fears Under the white moon rising something moving, something growls; we hail from an ancient dream we heed a different call we sing the song of things unseen we sing for no reason at all under the white moon rising something stirring something on the prowl can you hear the wolves singing "We were born to howl." -probably Jeremiah, but nobody is claiming it |
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