I'll try anything...............how do we get it if our doctor won't prescribe it?

Mary

get another doctor? til you do?

My husband has been on LDN for over 2 years now for his PD. When he first started LDN at the 4.5 mg dose, he was able to reduce from 2 caridopa/ levidopa down to one a day with no loss of function (along with one 5mg of selegeline). There has been no problem with taking LDN along with these medications.

However, earlier this year, he did a trial with the new PD drug rasageline (which meant he had to get off his selegeline first). However, he did not find that the rasageline was doing the job so after 6 weeks quit taking it and went back to the selegeline. During that time period however, he had declined somewhat and now has to take 2 to 3 carbidopa / levidopa a day instead of the one he was taking prior to the rasageline. I did read on some forum AFTERwards, that LDN and rasageline may not be compatible to take together.

So while he has been on LDN, we have not seen noticeable progression, except for this time period when on the rasegeline.

Mary,

Specialists, it seems, often are reluctant to prescribe LDN because they want to see clinical trials, and there are none for LDN and PD. Your best bet is to find a general practitioner or alternative minded doctor, and take some printouts from the website at www.lowdosenatrexone.org with you. My family has found two general practitioners who will prescribe it. They seem more openminded and are more likely to say it can't hurt you and are willing to see if it will help you.

And here are some sites you can go to where someone has put together some ldn info packets for doctors. These are more specific to MS but may still be helpful.

http://p220.ezboard.com/fldnlowdosen...picID=21.topic

Maureen's Complete Guide PDF
Maureen's info to help with Doctors
www.larrygc.com/ldn/ldndoctorsfolder.pdf

Maureen's Doctor Folder
Maureen's info to help with your Doctors (if you can't read PDF files)
www.larrygc.com/ldn/ldndoctorsfolder.doc

Maureen's Patient Guide (additional information)
Maureen's info to help us talk to our doctors
www.larrygc.com/ldn/ldnpatientguide.doc


Kathie

http://www.gazorpa.com has those files updated, too.

I will never take anything Other than LDN, no messing with success for me.

Just getting back from a life-changing vacation, I now have reason to stay healthy for a few more decades. LDN forever, hopefully without complications. One batch at a time, if the next 4 years can be as good as the last, me and my LDN will do just fine.

I am glad to hear you are doing great!
what do you feel about stress and MS? does stress bother you?
My sister Jana, -can't take the stress -
and she is still on copaxone which she gives herself daily injections...
I gave one to her yesterday...
she can't use the autoinjectors it scars her.


peace to you!

I'm afraid, like Maryfrances, that my doctor won't prescribe it. I'll ask, and let you know. Is there anything out there, over the counter, that equals it? What about availability in either European countries and/or Canada. My husband is leaving for Canada tomorrow and has another business trip in a few weeks to Scandinavia.

Any advice would be appreciated.

Thanks ...

To answer proudest-mama's question if there is something else out there beside LDN, maybe there is, it's dextromethorphan in the form of cough syrup bought in any drug store over the counter. Some people on this forum take about 5mg nightly (about one teaspoon). According to the work of Dr. Hong's group at the NIH, LDN and DM are opioid receptor antagonists and work in similar ways at low doses (femtomolar or 10 to the -14) to slow or stop neuroinflammatory disease.
Ashley

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage.

Li G, Cui G, Tzeng NS, Wei SJ, Wang T, Block ML, Hong JS.

Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. guorongl@med.unc.edu

Inflammation in the brain has increasingly been recognized to play an important role in the pathogenesis of several neurodegenerative disorders, including Parkinson's disease (PD). Progress in the search for effective therapeutic strategies that can halt this degenerative process remains limited. We previously showed that micromolar concentrations of dextromethorphan (DM), a major ingredient of widely used antitussive remedies, reduced the inflammation-mediated degeneration of dopaminergic neurons through the inhibition of microglial activation. In this study, we report that femto- and micromolar concentrations of DM (both pre- and post-treatment) showed equal efficacy in protecting lipopolysaccharide (LPS) -induced dopaminergic neuron death in midbrain neuron-glia cultures. Both concentrations of DM decreased LPS-induced release of nitric oxide, tumor necrosis factor-alpha, prostaglandin E2 and superoxide from microglia in comparable degrees. The important role of superoxide was demonstrated by DM's failure to show a neuroprotective effect in neuron-glia cultures from NADPH oxidase-deficient mice. These results suggest that the neuroprotective effect elicited by femtomolar concentrations of DM is mediated through the inhibition of LPS-induced proinflammatory factors, especially superoxide. These findings suggest a novel therapeutic concept of using "ultra-low" drug concentrations for the intervention of inflammation-related neurodegenerative diseases.

PMID: 15790998 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract

Hey! Been to NY? Look me up, I'm unattached

Yes, STRESS is a big key... nothing can battle that well, but LDN keeps much of the stress levels down.

I quit smoking, my last cigarette was 4/26/06

One year, three weeks, four days, 1 hour, 46 minutes and 27 seconds. 11702 cigarettes not smoked, saving $3,218.11. Life saved: 5 weeks, 5 days, 15 hours, 10 minutes.