If we are to judge the work as science, it is not that interesting. But if we judge it as engineering, it seems to me to be good stuff: a few percentage improvement in the QOL here, and a couple of percent improvement there, soon adds up.

If we could halve the severity of the symptoms or halve the rate of progression, as a very rough estimate, the age structure of the disease is such that we would probably reduce PD's impact by 90%.

It seems to me that there's room for a multitude of approaches, from the deeply theoretical (a sort of general relativity of the brain) to the practical (e.g. an aid for putting socks on).

soccertese mentions nasal levodopa. I share his interest in this. I've tried a few experiments using Stalevo dissolved in orange juice fired from a nebulizer. Rather like Bill Clinton I haven't inhaled. Worries about the purity of the liquid are stopping me from progressing.

John