Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 02-14-2014, 12:20 PM #1
badboy99 badboy99 is offline
Member
 
Join Date: Aug 2012
Location: On a shiny blue dot
Posts: 626
10 yr Member
badboy99 badboy99 is offline
Member
 
Join Date: Aug 2012
Location: On a shiny blue dot
Posts: 626
10 yr Member
Default Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a

Abstract

Parkinson’s disease patients exhibit progressive spreading of aggregated α-synuclein in the nervous system. This slow process follows a specific pattern in an inflamed tissue environment. Recent research suggests that prion-like mechanisms contribute to the propagation of α-synuclein pathology. Little is known about factors that might affect the prion-like behavior of misfolded α-synuclein. In this review, we suggest that neuroinflammation plays an important role. We discuss causes of inflammation in the olfactory bulb and gastrointestinal tract and how this may promote the initial misfolding and aggregation of α-synuclein, which might set in motion events that lead to Parkinson's disease neuropathology. We propose that neuroinflammation promotes the prion-like behavior of α-synuclein and that novel anti-inflammatory therapies targeting this mechanism could slow disease progression.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589652/
badboy99 is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
Tupelo3 (02-15-2014)

advertisement
Old 02-14-2014, 04:18 PM #2
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
10 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
10 yr Member
Default

The paper by Tome et al. represents what I believe to be the mainstream view that alpha-synuclein misfolding and aggregation play a key role in the pathogenesis of Parkinson's.

What's this got to do with us? In my opinion, a lot:
1. there is probably not just one etiology of PD - anything that speeds up the misfolding of alpha-synuclein is bad.
2. the toxin assault continues during the course of the disease.
For instance, aluminium and avian flu are mentioned.

Tome et al. speculate "that it will be possible to develop therapies which slow down the progression of PD by reducing the underlying inflammation and mitigating its effects on cell-to-cell α-syn transfer. In addition, it is conceivable that it would be possible to adopt a preventive strategy and lower the risk of developing PD by treating the triggers of inflammation in the olfactory or gastrointestinal system."

This way of looking at the disease should give us hope that there are things that we can do to slow progression. For instance, curcumin and exercise have been linked to a reduced risk of misfolding.

Tag johnt:alpha-synuclein

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
johnt is offline   Reply With QuoteReply With Quote
Old 02-14-2014, 05:33 PM #3
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
Default

i believe people taking ibuprofen and other anti-inflammatory drugs on a regular basis, i imagine for arthritis, chronic pain, have a lower incidence of pd.

in animal models, all sorts of inflammatory supplements reduce pd symptoms if the rat is pretreated before given a pd causing drug. i've read studies where ginseng, cucurmin, tea have that affect in rat experiments.
soccertese is offline   Reply With QuoteReply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? sim00 Parkinson's Disease 3 06-04-2012 09:39 AM
Classification as Prion Disease Conductor71 Parkinson's Disease 2 07-21-2011 02:37 AM
Genetic Risk Factor for Parkinson’s Linked to Increased Alpha-Synuclein olsen Parkinson's Disease 0 05-26-2011 01:07 PM
Gene protects against neurotoxins that spur inflammation and Parkinson's disease olsen Parkinson's Disease 0 04-04-2009 08:54 AM


All times are GMT -5. The time now is 10:27 AM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.