manganese and levodopa
I seem to recall reading that manganese parkinsonism does not respond to levodopa so that is one diagnostic criterion.
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Also, how is the Hinz protocol going? How long have you been doing that? Does it help? |
Hinz protocol
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If you do a search for Hinz it will bring up my past comments. |
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Hinz again
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Another study showed it to worked better than Sinemet. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1738871/. Hinz's mucuna is 40% levodopa vs the 4% founf naturally so perhaps it is spiked. In any case it takes a lot of capsules to get an equivalent dose. Each tsp is equivalent to 8 capsules. |
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gary, that article means nothing to me. sorry. it's in rats and in 1 part of the experiment they compare mucana against l-dopa by itself, that proves nothing. plus you can just modify your dose/timing with sinemet, you can't just look at 1 or 2 factors. there's price, convienence, purity, etc. as far as 40% l-dopa, your're taking 9tsps every 3 hrs? if 40% that would mean that you are taking more than 3tsps of l-dopa in every dose. the normal dose of l-dopa is 100mg every 3 hrs in admittedly a compressed pill. here's my calculation, i picked whole wheat to estimate the weight/cup of a grain as a starting point. 1lb=3.3cups 48tsps in 1 cup 474grams in 1lb 1lb/3.3cups = .30lbs/cup x 48tsp/cup = .0063 lb/tsp x 473gram/lb = 3grams/tsp x .40grams l-dopa/gram = 1.2grams of l-dopa/tsp of mucana so you are taking 3.6grams of l-dopa per dose? the normal dose for sinemet is 100mg l-dopa. maybe my calculations are off but common sense would tell you that 40% l-dopa in mucana makes no sense. as far as evolution goes, that makes no sense for a plant, the reason the plant has l-dopa i assume is as a defense mechanism, animals avoid it because they get dizzy when they eat it but 40% would be overkill, natural selection would have selected against it. i apologize if my calculations are off. |
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you need to do a little more research. carbidopa slows down the conversion of l-dopa to dopamine, l-dopa will pass thru the gut without carbidopa as will any similar amino acid. without the carbidopa almost all of the l-dopa would convert to dopamine outside the brain and dopamine doesn't pass the blood brain barrier. before carbidopa was mixed with l-dopa as a treament and patients were given only L-DOPA, doses over 10grams were common since you had to overwhelm the enzymes that broke down the l-dopa so some would get to the brain. patients suffered severe nausea. i was questioning how you create 40% mucana, 4% or 10% would make more sense. you'd just have too much dopamine getting created in your peripheral tissues. http://parkinsons.about.com/od/treat...amine_meds.htm |
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