Originally Posted by soccertese

congrats zanpar, both very useful links IMHO. I do take 1000micrograms of B-12 daily. i tried daily B-12 injections for a month, a friend who is a compounding pharmacist asked me to try them, felt no benefit.

Originally Posted by Muireann

I have only anecdotal evidence on this question and in time I'm sure the hardcore research will catch up. Yes, I think that correcting methylation is a worthy pursuit in efforts to heal from pd. But you need to have a sophisticated knowledge of biochemistry to fine tune methylation pathways. The folks who have that knowledge plus the clinical expertise are docs who work under the rubric of functional medicine, integrative medicine or Bioindividualised medicine.

Rather than throwing b12 or SAMe or glutathione at the problem in a random fashion they first run functional tests to see how u are performing as a methylator, not just looking at serum levels. Then they know what precursors to introduce, when and where and how to avoid triggering feedback inhibition. They also investigate underlying causes. Leaky gut seems to be extremely common. Triggers for that are common allergens like gluten, dairy or soy.

Folks are very focused on gluten as an issue but I suggest that you consider parasites and fungal overgrowth equally as they are just as implicated in dysbiosis. My functional med doc says that 80 percent of stool samples she submits are coming back positive for parasites (including my own and an acquaintance with pd). The problem is there if you look for it. This creates two problems. Toxins getting thru and malnutrition. I have shown up some major nutritional deficiencies which are now being corrected. I am also being treated for fungal overgrowth in gut as well as parasite. There's a long road ahead. Parasites are not easy to eliminate.

One such doc I spoke to said that when you treat such underlying conditions in pwps, their symptoms either abate or vanish completely. Worth a try. Pd aside, we'd all benefit from cleaning up our gut.

Originally Posted by Muireann

Soccertease, exactly where in the terms of use on this forum does it say I have to be 'qualified' to contribute to a discussion here? Are you trying to imply a right to moderate posts now?

I think other contributors to this thread understand the points I'm making. At least they're not coming back at me in SHOUTY block capitals

Originally Posted by soccertese

Read my post again. I said I thought noone here was qualified to discuss this in a meaningful way, i didn't say there should be no discussion. It seems everyone approaches this topic with their opinions set in concrete and only look for research that supports their opinion.

yes, i got angry when you said that study was meaningless, i totally disagree with you. especially since I tried IV glutathione and got no benefit. If that study had occurred before I got sucked in by the glutathione hype i would have saved hundreds of dollars.

Originally Posted by Muireann

Soccertease, I'm not quoting research to support my opinion. I'm simply proposing a more open minded approach to our problems. Iv glutathione may not improve most people's pd for a number of possible reasons:

1. They have additional coexisting methylation defects.

2. You can't leave the iv in for long enough.

3. It is a challenge to normalise anybody's physiology once they are on pd meds.

Personally, I think what is needed is to correct the methylation process itself so the person produces their own glutathione.

Originally Posted by Muireann

For a good overview of how complicated methylation is, listen to

http://www.blogtalkradio.com/elevate...dr-tim-jackson