http://amec.glp.net/c/document_libra...DLFE-20239.pdf

i remembered reading that sinemet CR half life is enhanced by food, was researching this and saw this article again, great discussion of the major L-DOPA , L-DOPA VS DOPAMINE AGONIST clinical trials.

i found this observation interesting, might be a little hard to read, had to reassemble it after cutting from pdf:

In the early 1990s, a number of in vitro studies demonstrated that high doses of LD can be toxic to dopaminergic neurons in cell culture, 30–32 causing some PD specialists to recommend withholding LD for as long as possible. 33 Since that time, data have accumulated showing that LD may also have protective effects for cultured dopamine neurons, depending on experimental conditions, such as presence or absence of glia 34,35 or ascorbic acid, 36,37 as well as LD dose used. 38 In addition, many in vivo
studies could not find evidence of LD-induced neurodegeneration in normal rodents, 39 primates, 40 and nonparkinsonian humans,
41 and some have even reported neuroprotective effects of LD on midbrain dopaminergic neurons. 42,43 Of particular interest are pathology reports from patients with essential tremor or dopa-responsive dystonia who had been chronically exposed to large amounts of LD over many years. None of these patients have shown evidence of substantia nigra degeneration at autopsy.