http://brainblogger.com/2014/03/17/i...isease-entity/

If Dr. Wlassoff is correct, our researchers have a herculean task a head of them. Not only trying to seek a cure or effective treatment for PD but knowing which entity they have been working on. Its going to be a long ride folks so buckle up & hang on.

Harry
Its 6 years that i have been diagnosed and from the beginning i heard people talking about PD in this way and explaining that it is the likely reason some people may do well in a clinical trial while others have little benefit from the same treatment. Perhaps the continual advances in genetic typing will solve this quite soon, Im optimistic.

Dilmar, I can only hope that you're right.

It's a tough issue. At least MJFF has tackled the problem with their longitudinal Parkinson's Progressive Markers Initiative (PPMI). They've invested 50 million+ around the world to carefully collect biological evidence from hundreds of trial participants to track disease progression over 5 years. The data collected is available to any investigator who wants it. Something about the true nature of Parkinsonisms will surely emerge. Until targetable biomarkers are discovered, clinical trials will continue to miss the mark.