Parkinson's Disease Tulip


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Old 06-17-2014, 12:13 PM #1
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Default Fetal-cell Revival for Parkinson’s

http://nwpf.org/stay-informed/news/2...-cell-revival/
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Old 06-17-2014, 02:00 PM #2
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Default NOW this comes back up?

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Originally Posted by soccertese View Post
Sorry to be the DebbieDowner, but I find this whole thing suspect. Just as autologous stem cells are really seeming to gain traction, now this fetal stem cell research re-appears? The authors do not mention a huge issue with fetal stem cells: they are not your own! Fetal stem cells will never be recognized by the body as self. There will always be issues with rejection unless one wants to take anti-rejection drugs for the rest of his or her life...creating entirely new issues with side effects. To me it seems like the time and talents of these scientists could be much better spent on autologous stem cells. I really hope this is not some attempt to have another "failed" stem cell research on a global level, which would do real harm to autologous stem cell work and set it back years. Someone tell me my cynicism is misplaced!
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Old 06-17-2014, 02:30 PM #3
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Originally Posted by lurkingforacure View Post
Sorry to be the DebbieDowner, but I find this whole thing suspect. Just as autologous stem cells are really seeming to gain traction, now this fetal stem cell research re-appears? The authors do not mention a huge issue with fetal stem cells: they are not your own! Fetal stem cells will never be recognized by the body as self. There will always be issues with rejection unless one wants to take anti-rejection drugs for the rest of his or her life...creating entirely new issues with side effects. To me it seems like the time and talents of these scientists could be much better spent on autologous stem cells. I really hope this is not some attempt to have another "failed" stem cell research on a global level, which would do real harm to autologous stem cell work and set it back years. Someone tell me my cynicism is misplaced!
my understanding is even in the original transplants back in late 80's, 90's, no immunosuppressive drugs were used. not an issue.

https://www.landesbioscience.com/pdf/Baehr13Paul.pdf
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Old 06-18-2014, 10:18 AM #4
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Default there was mixed immunosuppression....

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Originally Posted by soccertese View Post
my understanding is even in the original transplants back in late 80's, 90's, no immunosuppressive drugs were used. not an issue.

https://www.landesbioscience.com/pdf/Baehr13Paul.pdf
ST, looks like historically, different centers use different standards of immunosuppression, I can't get the part of the article you cited to copy, but it's on ppgs. 6, 7 under "Is Immunosupression Necessary". How would fetal cells be any different from a liver or kidney that was transplanted? The brain may have temporary immunity to foreign cells once they are actually inside and past the BBB, but I don't think that apparent immunity lasts.
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Old 06-18-2014, 05:18 PM #5
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Yes,
20 yrs ago as a teary eyed 35 yr old newly diagnosed PWP I was told by a MDS the same thing about immunosuppressants being needed and the fact that the foetal cell implants on PWP done in I think Sweden hadn't taken they found post mortem.
I don't really know that much to date as I don't follow that much anymore but that was then.
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