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07-17-2014, 04:41 PM | #1 | ||
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Magnate
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best article i've seen on how l-dopa is absorbed and how that absorption can be affected by protein.
discusses potential affect in early and later stages and suggests things to try to improve absorption and lessen fluctuations. didn't notice this initially but mentions fava having l-dopa in a different structure than synthetic? " The beans are a natural food which contains L-dopa in a physicochemical form different from that of tablet formulations and may thus have some use in the management of Parkinsonian motor fluctuations." i assume old article, most recent literature citation was 1992 and doesn't mention stalevo or duodopa but interestingly does mention experimental IV and nasal tube delivery getting around the protein problem in the duodenum absorption but not the BBB. i found this interesting, exactly why getting the l-dopa out of the stomach asap is important if you have on/off periods: "L-Dopa is optimally absorbed from the duodenum and proximal jejunum.[16] The drug is not absorbed across gastric mucosa,[17] but oral doses are dependent on gastric emptying for access to absorption sites. The rate of gastric emptying is chiefly determined by the energy content of food and is inversely proportional to the energy density of meal.[18] Thus fat will retard gastric emptying to greater degree than either protein or carbohydrate. Low gastric acidity slows emptying [19] although routine administration of antacids to Parkinsonian patients does not improve L-dopa absorption.[20] Some types of dietary fiber increase food viscosity and slow gastric emptying.[21] The gastric mucosa contains the enzyme dopa decarboxylase,[22] which will catalyze unwanted conversion of L-dopa to dopamine, reducing the amount of L-dopa available for subsequent absorption from doses affected by delayed gastric emptying." http://www.parkinsons-information-ex...chive/097.html Last edited by soccertese; 07-17-2014 at 05:31 PM. |
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07-19-2014, 06:47 AM | #2 | |||
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Member
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I don't understand chemistry, but my body seems to understand plants and knows what I need...Fava beans and plants are amazing. God seemed to put everything in them that I need. People are all diifferent and the causes of their PD can range from toxic chemicals exposure .........to bug sprays on food sources.......welding fumes......hereditary .....blows in the head.....foot injury. But, favas work for me, for that I am so grateful. They are a lot of physical work...but they work so well against my symptoms. I would surely be in trouble with my PD without them. I don't want to go to pharmaceuticals and doctors for something I can control so well on my own. Will be planting a fall crop on the 26th of JUly . God Bless
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