[badboy99]

Glutathione Supplementation Increases Body Stores, May Be Significant for Overall Health Maintenance
By Greg Arnold, DC, CSCS, June 30, 2014, abstracted from “Randomized controlled trial of oral glutathione supplementation on body stores of glutathione” in the May 5, 2014 issue of the European Journal of Nutrition

Glutathione is the major antioxidant made by the body inside each cell. It has numerous functions, including protection against cell damage (oxidative stress), detoxification, and maintenance of the immune system (1,2). Low levels of glutathione have been shown to impair immune system function (3) and increase susceptibility to disease-causing organisms (4) and cell damage (5), all of which can lead to cancer (6), cardiovascular diseases, arthritis and diabetes (7,8).

Now a new study (9) suggests that oral glutathione supplementation in humans can help increase levels in the body and may have a significant impact on heath maintenance. The study involved 54 non-smoking adults (13 men, 41 women) aged 36 to 57. They were given either 250 milligrams (two 125-mg capsules = 18 subjects), 1,000 mg (two 500-mg capsules = 20 subjects), or a placebo (16 subjects), per day of glutathione for 6 months. Blood samples were taken before the study and at months 1, 3, 6, and 7. After 6 months, all subjects stopped supplementation for 1 month (called the “washout period”) and then had blood samples taken to see if any gains observed during the 6 months of supplementation were reversed.

After 6 months, those in the 250-mg group saw increases of 17% throughout the blood but a 29% increase inside red blood cells (p < 0.05). In the 1,000-mg group, 30% increases were seen in red blood cells, white blood cells, and lymph cells along with a 260% increase in buccal cells (found in the mouth) (p < 0.05). In both groups, glutathione levels returned to the levels seen before the study started after the 1-month washout period. No significant changes were seen in the placebo group at any of the measurement periods.

What’s more, cell damage (oxidative stress) decreased in the supplement group. Using a ratio comparing the levels of damaged to undamaged glutathione that is known to be an indicator of oxidative stress (10), researchers saw a 10.3% ratio reduction (indicating less cell damage in the body) in the 250-mg group (0.39 to 0.35, p < 0.05) and a 17.2% ratio reduction in the 1,000-mg group (0.380 to 0.315, p < 0.05).

These findings may have implications regarding the treatment of diseases associated with reduced GSH levels (6), especially HIV infection, as depletion of glutathione levels is thought to be an important factor in the disease’s progression (11, 12). The 264% increase in mouth cells correlates with previous research showing higher levels of glutathione levels to decrease the risk of mouth cancer (13).

They concluded that “These findings show, for the first time, that daily consumption of glutathione supplements was effective at increasing body compartment stores of glutathione.”

http://www.now-university.com/Librar...tem/100905.htm

[soccertese]

that is interesting, i thought it was broken down 100% into it's constituent amino acids in the stomach. maybe the cells reassemble them?

do you take it and if so how much and for how long??

i don't think anyone knows for sure if you take it orarally though if it gets into the brain.

and HAUSER did a small, double blind study with IV glutathione and pd patients at the USF and saw no statistically sig. benefit.
http://www.ncbi.nlm.nih.gov/pubmed/19230029

i guess it can't hurt you, might help.

researcher Laurie Mischley did a study on NASAL GT, hasn't published the paper yet, just testing safety
http://clinicaltrials.gov/show/NCT01398748
i heard her speak, she said she prescribes it to her patients for possible neuroprotection, not symptomatic relief, but i heard her again and she related the story of how it helped 2 elderly woman feel better. i talked to someone in her trial who got the pkacebo and she said she felt better.

survey
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651682/

[soccertese]

you got a link to the original paper, what you posted was from a supplement mfg's website "abstracted" by a chiropracter.

[badboy99]

https://www.ncbi.nlm.nih.gov/pubmed/24791752

Abstract
PURPOSE:
Glutathione (GSH), the most abundant endogenous antioxidant, is a critical regulator of oxidative stress and immune function. While oral GSH has been shown to be bioavailable in laboratory animal models, its efficacy in humans has not been established. Our objective was to determine the long-term effectiveness of oral GSH supplementation on body stores of GSH in healthy adults.
METHODS:
A 6-month randomized, double-blinded, placebo-controlled trial of oral GSH (250 or 1,000 mg/day) on GSH levels in blood, erythrocytes, plasma, lymphocytes and exfoliated buccal mucosal cells was conducted in 54 non-smoking adults. Secondary outcomes on a subset of subjects included a battery of immune markers.
RESULTS:
GSH levels in blood increased after 1, 3 and 6 months versus baseline at both doses. At 6 months, mean GSH levels increased 30-35 % in erythrocytes, plasma and lymphocytes and 260 % in buccal cells in the high-dose group (P < 0.05). GSH levels increased 17 and 29 % in blood and erythrocytes, respectively, in the low-dose group (P < 0.05). In most cases, the increases were dose and time dependent, and levels returned to baseline after a 1-month washout period. A reduction in oxidative stress in both GSH dose groups was indicated by decreases in the oxidized to reduced glutathione ratio in whole blood after 6 months. Natural killer cytotoxicity increased >twofold in the high-dose group versus placebo (P < 0.05) at 3 months.
CONCLUSIONS:
These findings show, for the first time, that daily consumption of GSH supplements was effective at increasing body compartment stores of GSH.

[badboy99]

http://link.springer.com/article/10....394-014-0706-z

[badboy99]

Reduced Glutathione 500mg

http://www.amazon.com/Jarrow-Formula...athione&dpPl=1

Reduced Glutathione Sublingual Complex, 50mg

http://www.amazon.com/Source-Natural...ds=glutathione

[badboy99]

Dr. Perlmutter recommends IV Reduced Glutathione @ 3000mg - 3 times a week.

[olsen]

The objective of this study was to evaluate the safety, tolerability, and preliminary efficacy of intravenous glutathione in Parkinson's disease (PD) patients. This was a randomized, placebo-controlled, double-blind, pilot trial in subjects with PD whose motor symptoms were not adequately controlled with their current medication regimen. Subjects were randomly assigned to receive intravenous glutathione 1,400 mg or placebo administered three times a week for 4 weeks. Twenty-one subjects were randomly assigned, 11 to glutathione and 10 to placebo. One subject who was assigned to glutathione withdrew from the study for personal reasons prior to undergoing any postrandomization efficacy assessments. Glutathione was well tolerated and there were no withdrawals because of adverse events in either group. Reported adverse events were similar in the two groups. There were no significant differences in changes in Unified Parkinson's Disease Rating Scale (UPDRS) scores. Over the 4 weeks of study medication administration, UPDRS ADL + motor scores improved by a mean of 2.8 units more in the glutathione group (P = 0.32), and over the subsequent 8 weeks worsened by a mean of 3.5 units more in the glutathione group (P = 0.54). Glutathione was well tolerated and no safety concerns were identified. Preliminary efficacy data suggest the possibility of a mild symptomatic effect, but this remains to be evaluated in a larger study.

http://www.ncbi.nlm.nih.gov/pubmed/19230029

NOTE: Dr. Perlmutter was second author on this published paper in which there were minimal gains reported after 4 weeks, and a worsening in rating scale after 8 weeks.

[soccertese]

Originally Posted by olsen

The objective of this study was to evaluate the safety, tolerability, and preliminary efficacy of intravenous glutathione in Parkinson's disease (PD) patients. This was a randomized, placebo-controlled, double-blind, pilot trial in subjects with PD whose motor symptoms were not adequately controlled with their current medication regimen. Subjects were randomly assigned to receive intravenous glutathione 1,400 mg or placebo administered three times a week for 4 weeks. Twenty-one subjects were randomly assigned, 11 to glutathione and 10 to placebo. One subject who was assigned to glutathione withdrew from the study for personal reasons prior to undergoing any postrandomization efficacy assessments. Glutathione was well tolerated and there were no withdrawals because of adverse events in either group. Reported adverse events were similar in the two groups. There were no significant differences in changes in Unified Parkinson's Disease Rating Scale (UPDRS) scores. Over the 4 weeks of study medication administration, UPDRS ADL + motor scores improved by a mean of 2.8 units more in the glutathione group (P = 0.32), and over the subsequent 8 weeks worsened by a mean of 3.5 units more in the glutathione group (P = 0.54). Glutathione was well tolerated and no safety concerns were identified. Preliminary efficacy data suggest the possibility of a mild symptomatic effect, but this remains to be evaluated in a larger study.

http://www.ncbi.nlm.nih.gov/pubmed/19230029

NOTE: Dr. Perlmutter was second author on this published paper in which there were minimal gains reported after 4 weeks, and a worsening in rating scale after 8 weeks.

yet you'll never see perlmuttter mention this study and i don't know if anyone tried to get funding for another similar trial.. i talked to someone who was in the placebo group of a nasal glutathione study who thought she felt better, might be more proof of how strong the placebo affect is. but a lot of people people pay $100's to naturpaths/dr''s to get a nasal glut RX and i believe it costs $75 for a months supply of nasal glut, i think with the hope it will at the minimum slow progression. maybe some benefit, some don't, but i'm hoping for a big study on nasal glut from someone after the safety trial results are finally published.
how PBS legitimizes perlmutter in their fund raising efforts is imho truly shameful.

[soccertese]

Originally Posted by soccertese

yet you'll never see perlmuttter mention this study and i don't know if anyone tried to get funding for another similar trial.. i talked to someone who was in the placebo group of a nasal glutathione study who thought she felt better, might be more proof of how strong the placebo affect is. but a lot of people people pay $100's to naturpaths/dr''s to get a nasal glut RX and i believe it costs $75 for a months supply of nasal glut, i think with the hope it will at the minimum slow progression. maybe some benefit, some don't, but i'm hoping for a big study on nasal glut from someone after the safety trial results are finally published.
how PBS legitimizes perlmutter in their fund raising efforts is imho truly shameful.

just double checking if it is the same perlmutter and it is, here's some of his articles
http://www.researchgate.net/profile/...2/publications
i've mentioned that study many times but never noticed perlmutter was an author, thanks!