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08-19-2014, 05:49 PM | #1 | ||
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Magnate
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.pdf dated march 2014, not sure when this was written, very interesting at least to me.
sorry if it's already been posted. http://iospress.metapress.com/conten...2/fulltext.pdf Journal of Parkinson’s Disease 4 (2014) 1–13 DOI 10.3233/JPD-130335 IOS Press 1 Review Interventions that Improve Body and Brain Bioenergetics for Parkinson’s Disease Risk Reduction and Therapy Mark P. Mattson Laboratory of Neuroscience, National Institute on Aging Intramural Research Program, Baltimore, MD, USA Department of Neuroscience, Johns Hopkins University School of Medicne, Baltimore, MD, USA Abstract . Studies of Parkinson’s disease (PD) patients, animal models and pathogenic actions of genetic mutations that cause familial PD have established that neuronal bioenergetics are compromised with brainstem and midbrain monoaminergic neurons being particularly vulnerable. Peripheral insulin resistance and diabetes in midlife may increase the risk of PD, and diet and lifestyle changes that increase insulin sensitivity (exercise and intermittent energy restriction) can counteract neurodegenerative processes and improve functional outcome in animal models. Insulin sensitizing glucagon-like peptide 1 (GLP-1) analogs are beneficial in animal models of PD, and the results of an initial clinical trial in PD patients are promising. In addition to improving peripheral and brain energy metabolism, exercise, intermittent energy restriction and GLP-1 analogs may bolster neuronal adaptive stress response pathways that enhance neurotrophic signaling, DNA repair, proteostasis and mitochondrial biogenesis. |
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08-19-2014, 08:14 PM | #2 | ||
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Member
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Quote:
Does anyone follow a regular course of intermittent fasting, and if so, what have been the results? |
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08-19-2014, 09:28 PM | #3 | ||
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Magnate
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the only thing i practice is intermittent slowness
i think researchers are searching for drugs which switch on the same genes as calorie restriction does, part of longetivity research. |
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