can't wait but it's likely going to be very expensive. obvious benefits for quick "on".
http://www.fiercebiotech.com/story/c...m_campaign=rss

Does anyone know if a drug's side effects from oral ingestion are also seen if it is inhaled? Can't help but wonder if sinemet's side effects will be less if it doesn't have to go through the GI tract.

i assume you'll have to worry less about reduced l-dopa absorption due to eating protein, constipation and whatever else seems to mysteriously temporarily reduce C/L effectiveness. i know there are times when my C/L isn't kicking in and wouldn't it be wonderful to have inhaled l-dopa available as a way to troubleshoot whether it is something in your digestive system that's causing the problem? it still isn't going to help with AA interference crossing the BBB if you eat a lot of protein.

i doubt if side affects are less but theoretically you might be able to take less C/L if you know you can quickly "top up" with the inhaler. i think you still have to take carbidopa orally in the form of oral C/L. it's intended as a rescue drug like apomorphine, doubt insurance companies would pay for it to be your main parkinson's drug, plus i wouldn't want to inhale it 8 times a day.

i think it might reduce azilect and comtan THAT is prescribed to lengthen "on time" of C/L.
i've read somewhere elderly have problems with inhalers, irritates lungs too much? think i read that in an investor presentation by the company developing a competing tech, oral apomorphine which is a rescue drug.

which side affects are you referring to?

https://www.michaeljfox.org/foundati...haled-levodopa

oh, my, I can start with the orange pee, the dizziness, those listed on every bottle from the pharmacy...

Was it you, ST, who said we only get 20% of ldopa that we eat? If that's correct, inhaling it will vastly increase how much of a 100mg dose gets to the brain, I would think. So while it may cost more, if we could get by with taking much less, because much less is needed because more gets to the brain via an inhaler, it may end up not being that much more expensive after all. Hope their Phase III is in our area

QUOTE=lurkingforacure;1092071]

Was it you, ST, who said we only get 20% of ldopa that we eat? If that's correct, inhaling it will vastly increase how much of a 100mg dose gets to the brain, I would think. So while it may cost more, if we could get by with taking much less, because much less is needed because more gets to the brain via an inhaler, it may end up not being that much more expensive after all. Hope their Phase III is in our area[/QUOTE]

Dose level for the Phase 2b started at 35mg and increased to 50mg. Volunteers self-administered as desired with an average of twice/day.

The phase 2 had multiple site locations. I would imagine the phase 3 will also.

In case folks are interested in registering for this trial: https://clinicaltrials.gov/ct2/show/NCT02240030.

My mom is considering it. The nearest site is 2hrs from my parents' house, which is tough because she is uncomfortable a lot of the time, but potentially doable.

We were disqualified from this because of cancer in the last five years. Very annoyingly, this criteria is not listed on the website, and the people who answered the call and did the registration did not ask about cancer history. It took filling out a massive form to learn that she was never eligible in the first place.