When visiting my doctor or reading books on PD by doctors they usually say take as much Sinemet you need and only cut back if you develop Dyskinesia.When I look thru the literature,I am amazed there are no studies testing the long rerm effects of Sinemet.There was one failed study done by Stanlry Fahn at Columbra that showed the more Sinemet you used the greaterv damage to the brain as showed on brain scans.He did not come to a conclusion as he said the group scanned was not large enough.but no followup trial was done.I have decided to take the least amoumt of Sinemet to keep me functional.I would to have your opinions. Stan