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09-12-2014, 06:09 PM | #1 | ||
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"Thanks for this!" says: | badboy99 (09-13-2014), Betsy859 (09-13-2014), Conductor71 (09-14-2014), GerryW (09-13-2014), lab rat (09-14-2014), MeAndPD (09-15-2014), olsen (09-13-2014), Stand Tall (09-13-2014), Tupelo3 (09-12-2014) |
09-14-2014, 09:00 AM | #2 | ||
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One of the researchers formerly with the Southwestern group mentioned in the articles is now at Iowa, here is a related article:
http://now.uiowa.edu/2014/04/protect...-caused-stress The compound being researched is related to Dimebone, which has been discussed here (search the forum). Here's the wiki on P3C7: "...P7C3 is a drug related to latrepirdine (dimebon), which has neuroprotective and proneurogenic effects, and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders. The precise mechanism of action through which these effects are exerted remains unclear as of 2010, but the pharmacological effects of P7C3 in vitro resemble those of endogenous proneurogenic peptides such as fibroblast growth factor 1, and the proneurogenic activity of P7C3 was around thirty times that of dimebon when they were compared side by side. P7C3 was chosen for further animal studies on the basis of favourable pharmacokinetic factors, such as its high oral bioavailability and long duration of action, but several other related compounds showed similar activity such as the more potent fluorinated analogue P7C3A20 which is up to ten times stronger again, and the methoxy analogue P7C3-OMe, for which it was determined that the (R) enantiomer is the active form...." I think we are going to ultimately find that stress causes illness via a cascade of events beginning with this or that enzyme, peptide, whatever, and we just manifest it in different ways and to differing degrees. I think it's interesting that grehlin, made in our gut, could be heavily linked to neuronal regrowth. Validates those who earlier claimed PD began in the gut, where they have found alpha-synuclein clumps predating PD symptoms. |
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"Thanks for this!" says: | anagirl (09-14-2014), Betsy859 (09-15-2014), Conductor71 (09-14-2014), GerryW (09-14-2014), lab rat (09-14-2014), Stand Tall (09-14-2014), Tupelo3 (09-15-2014) |
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