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11-07-2014, 06:16 PM | #1 | ||
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Intranasal GDNF delivery appears to have the potential to reverse PD symptoms! Why isn't this being fast tracked?
http://www.northeastern.edu/news/in-...gene-delivery/ https://www.michaeljfox.org/foundati...p?grant_id=511 http://www.northeastern.edu/news/201...nt-parkinsons/ |
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11-07-2014, 07:42 PM | #2 | ||
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I think it is on the fast track - should be ready in... 2040
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"Thanks for this!" says: | badboy99 (11-08-2014) |
11-07-2014, 09:52 PM | #3 | ||
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11-08-2014, 12:06 AM | #4 | ||
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11-08-2014, 02:51 AM | #5 | ||
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I wonder if PD community, people like us can start fundraising campaign to fund early phase.
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11-08-2014, 10:06 AM | #6 | ||
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http://www.cureparkinsons.org.uk/ They are presently funding a GDNF trial for infusing GDNF directly into the brain. http://www.cureparkinsons.org.uk/gdnf-study-p GDNF trial study video http://www.parkinsons.org.uk/content...dnf-parkinsons |
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11-08-2014, 01:18 PM | #7 | ||
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Here is an interim report that I found on MJFF. I couldn't find anything more recent either on MJFF or PubMed.
INTERIM PROGRESS REPORT Professor Waszczak reported that intranasal administration of GDNF has a neuroprotective efficacy in a pre-clinical model of Parkinson’s disease. Neuroprotection is also achieved by stereotaxic injection of gene vectors expression GDNF into the striatum. Other studies show that 125I-GDNF undergoes receptor mediated retrograde transport from the striatum to the midbrain dopaminergic neuron cell bodies. To distinguish gene-derived from endogenous GDNF, we used a gene vector expressing GDNF with an epitope tag. This gene vector was intranasally administered to test whether the intranasal (gene-derived) GDNF would appear within the midbrain dopaminergic neuron cell bodies. Significant technical issues, such as delivery losses due to the “sticky” nature of gene vector, prevented reproducible adequate transfection following intranasal administration. While a sensitive histological/immunohistochemical procedure for visualizing trace GDNFflag in intracellular vesicles was developed, further studies are required to properly test whether intranasal, gene-derived, GDNF can make direct contact with receptors expressed by midbrain dopaminergic neurons. April 2012 |
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11-08-2014, 03:32 PM | #8 | ||
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[QUOTE=zanpar321;1106894]Great idea Lana. Also, I wonder of Cure Parkinson's Trust UK would consider helping fund such a study on Intranasal GDNF? They are apparently a patient lead organization. Does anyone know a contact there to talk to regarding this?
Peggy, who is a member of Neurotalk knows Tom (founder of Cure Parkinons) and might be able to help. I am forwarding this info to Peggy right now. The links posted here from 2013. Did anyone find more info or current status of the project? |
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11-08-2014, 03:45 PM | #9 | ||
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Quote:
girija |
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11-08-2014, 03:52 PM | #10 | ||
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[PDF]View Poster - Northeastern University
www.northeastern.edu/rise/wp-content/.../Aly.pdf Northeastern University Brendan T. Harmon. †. , Mark J. Cooper. §. , Ozge Sesenoglu-Laird. §. , Linas Padegimas. § and Barbara L. Waszczak. †. †. Department of Pharmaceutical ... |
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"Thanks for this!" says: | olsen (11-09-2014) |
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