We recruited three patients with newly diagnosed PD. They were not under anti-Parkinson's therapy. Plasmatic thiamine was within healthy reference range. We performed the Unified Parkinson's Disease Rating Scale (UPDRS) and started a parenteral therapy with high doses of thiamine. The therapy led to a considerable improvement in the motor part of the UPDRS ranging from 31.3% to 77.3%. From this clinical observation, it is reasonable to infer that a focal, severe thiamine deficiency due to a dysfunction of thiamine metabolism could cause a selective neuronal damage in the centres that are typically hit in this disease. Injection of high doses of thiamine was effective in reversing the symptoms, suggesting that the abnormalities in thiamine-dependent processes could be overcome by diffusion-mediated transport at supranormal thiamine concentrations.

http://www.ncbi.nlm.nih.gov/pubmed/23986125

http://www.neurores.org/index.php/ne...e/view/155/156

Amazing...

This brought tears to my eyes.

It seems promising but these are only small case studies so far. I believe thiamine is necessary for producing ATP energy for the mitochondria so if it's deficient that would explain how replenishing would help. Need to do more research on this!

Sugar depletes Thiamine. This may be why my tremors are worse after eating sugar/carbs!

http://vitaminsandminerals.awardspac...ptoms-sources/