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01-26-2015, 04:42 PM | #1 | ||
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We recruited three patients with newly diagnosed PD. They were not under anti-Parkinson's therapy. Plasmatic thiamine was within healthy reference range. We performed the Unified Parkinson's Disease Rating Scale (UPDRS) and started a parenteral therapy with high doses of thiamine. The therapy led to a considerable improvement in the motor part of the UPDRS ranging from 31.3% to 77.3%. From this clinical observation, it is reasonable to infer that a focal, severe thiamine deficiency due to a dysfunction of thiamine metabolism could cause a selective neuronal damage in the centres that are typically hit in this disease. Injection of high doses of thiamine was effective in reversing the symptoms, suggesting that the abnormalities in thiamine-dependent processes could be overcome by diffusion-mediated transport at supranormal thiamine concentrations.
http://www.ncbi.nlm.nih.gov/pubmed/23986125 Last edited by zanpar321; 01-26-2015 at 05:16 PM. |
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"Thanks for this!" says: | anagirl (01-26-2015), badboy99 (01-26-2015), Conductor71 (01-27-2015), GerryW (01-26-2015), mrsD (01-26-2015), olsen (01-30-2015), parkinsons here-now (01-02-2021), shcg (03-04-2015), sim00 (01-27-2015) |
01-26-2015, 08:03 PM | #2 | ||
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01-26-2015, 09:05 PM | #3 | ||
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Amazing...
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01-26-2015, 09:25 PM | #4 | ||
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This brought tears to my eyes.
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01-26-2015, 11:14 PM | #5 | ||
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It seems promising but these are only small case studies so far. I believe thiamine is necessary for producing ATP energy for the mitochondria so if it's deficient that would explain how replenishing would help. Need to do more research on this!
Last edited by zanpar321; 01-26-2015 at 11:35 PM. |
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01-27-2015, 12:03 AM | #6 | ||
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Quote:
http://vitaminsandminerals.awardspac...ptoms-sources/ |
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01-27-2015, 11:06 AM | #7 | ||
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Another report on parenteral thiamine. Anyone know why a thiamine injection or iv works better than pills?
The Beneficial Role of Thiamine in Parkinson’s Disease: Preliminary Report Abstract Parkinson’s disease (PD) is the second most common form of neuro-degeneration in the elderly population. PD is clinically characterized by tremors, rigidity, slowness of movement and postural imbalance. A significant association has been demonstrated between PD and low levels of serum thiamine. Five PD patients presented with stone face, right-hand tremors, Parkinsonian gait and bradykinesia with occasional freezing. Two patients presented with sialorrhea and the plasma transkelosase activity was low in one patient. All of the patients received 100 - 200 mg daily doses of parenteral thiamine. Within days of thiamine treatment, the patients had smiles on their faces, walked normally with longer steps, increased their arm swings, and experienced no tremors or sialorrhea. Three patients did not require carbidopa and levodopa without effects on their movements. Thiamine may benefit to PD. Further investigation of thiamine in PD patients is needed. Keywords: Thiamine; Transketolase; Parkinson’s disease; Movement |
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01-27-2015, 11:15 AM | #8 | ||
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Quote:
T. E. Friedman, T. C. Kmieckiak, P. K. Keegan and B. B. Sheft, “The Absorption, Destruction, and Excretion of Orally Administered Thiamine by Human Subjects,” Gastroenterology, Vol. 11, 1948, pp. 100-114. |
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01-27-2015, 12:00 PM | #9 | ||
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01-27-2015, 02:20 PM | #10 | ||
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http://neurotalk.psychcentral.com/ar.../t-210912.html so if Thiamine is directly connected to the use of sugar/glucose to produce ATP energy then we may be onto something significant here! Let the research continue! |
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"Thanks for this!" says: | Betsy859 (01-30-2015) |
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