[Bogusia]

It looks like not only deficiency of B1 but also deficiency of B2, and probably other B complex vitamins play role in PD. I wish doctors would test for these deficiencies and don't assume that we get enough B vitamins from food. Even if we follow healthy diet what if for whatever reasons our body can't absorb or process B vitamins properly.


Brazilian Journal of Medical and Biological Research
On-line version ISSN 1414-431X
Braz J Med Biol Res vol.36 no.10 Ribeirão Preto Oct. 2003
http://dx.doi.org/10.1590/S0100-879X2003001000019

Braz J Med Biol Res, October 2003, Volume 36(10) 1409-1417

High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients

C.G. Coimbra1,2 and V.B.C. Junqueira3,4

1Setor de Neurologia, Hospital do Servidor Público Municipal de São Paulo, São Paulo, SP, Brasil
2Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
3Disciplina de Geriatria, Departamento de Medicina, Centro de Estudos do Envelhecimento, Universidade Federal de São Paulo, São Paulo, SP, Brasil
4VITÆ - Cromatografia Líquida em Análises Clínicas S/C Ltda., São Paulo, SP, Brasil

Abstract

Abnormal riboflavin status in the absence of a dietary deficiency was detected in 31 consecutive outpatients with Parkinson's disease (PD), while the classical determinants of homocysteine levels (B6, folic acid, and B12) were usually within normal limits. In contrast, only 3 of 10 consecutive outpatients with dementia without previous stroke had abnormal riboflavin status. The data for 12 patients who did not complete 6 months of therapy or did not comply with the proposed treatment paradigm were excluded from analysis. Nineteen PD patients (8 males and 11 females, mean age ± SD = 66.2 ± 8.6 years; 3, 3, 2, 5, and 6 patients in Hoehn and Yahr stages I to V) received riboflavin orally (30 mg every 8 h) plus their usual symptomatic medications and all red meat was eliminated from their diet. After 1 month the riboflavin status of the patients was normalized from 106.4 ± 34.9 to 179.2 ± 23 ng/ml (N = 9). Motor capacity was measured by a modification of the scoring system of Hoehn and Yahr, which reports motor capacity as percent. All 19 patients who completed 6 months of treatment showed improved motor capacity during the first three months and most reached a plateau while 5/19 continued to improve in the 3- to 6-month interval. Their average motor capacity increased from 44 to 71% after 6 months, increasing significantly every month compared with their own pretreatment status (P < 0.001, Wilcoxon signed rank test). Discontinuation of riboflavin for several days did not impair motor capacity and yellowish urine was the only side effect observed. The data show that the proposed treatment improves the clinical condition of PD patients. Riboflavin-sensitive mechanisms involved in PD may include glutathione depletion, cumulative mitochondrial DNA mutations, disturbed mitochondrial protein complexes, and abnormal iron metabolism. More studies are required to identify the mechanisms involved.

Key words: Parkinson's disease, Riboflavin, Flavin-adenine dinucleotide, Glutathione, Iron, Hemin


http://www.scielo.br/scielo.php?pid=...pt=sci_arttext

[lurkingforacure]

I think testing is a waste here, as the standard tests measure what is in the blood and it is it what is inside the cell that matters.

Also, what impact would a measurement have? I think the test subjects in the thiamine Vietnamese American study from 2012 all had thiamine levels in the "normal" range, but they all had PD and all felt horrible and all benefitted immensely from thiamine supplementation.

"Normal" is relative as well. Maybe I need 25mg/day of some nutrient to function optimally, someone else may need 100mg/day.

[Aunt Bean]

I have been taking B complex 100 for over 2o years now. Was having extreme back and neck pain when I started it. I read about b complex in a journal at the chiropractors office, that it was absolutely necessary for people who were vegetarian (which I am practically) Started it and haven't been back to a chiropractor since.