This is pretty scientific, but deals extensively with nicotinamide and PD. Over my head, but if anyone here can help decipher it, we'd appreciate it:

http://qjmed.oxfordjournals.org/content/98/3/215

If I read it right, it is a bit scary in that some products of reactions in our heads may be trapped inside the BBB, unable to get out, thus increasing the damage

I think that it is an interesting paper.

What the authors did was to review the work of others which showed that an enzyme called nicotinamide N-methyltransferase (NNMT) is normally found in the brain and that it can catalyse the production of a compound called MPP+ (1-methyl-4-phenylpyridinium) from a normal component of metabolism. MPP+ is known to be cytotoxic. All of this, as a biomedical scientist, looks sensible to me.

There is a lot of research interest in the possible link between MPP+ and PD (a PubMed search ("1-methyl-4-phenylpyridinium" AND "parkinson") retrieves 403 papers.

As far as I can see all of those papers have looked at the effects of MPP+ on neurons grown in cell culture. This is valuable work but it is not yet of therapeutic importance - for example, there are no papers which show that clinical trials have demonstrated that lowering the levels of MPP+ in the brains of people with PD is helpful.

Hi Badboy,
My son is a medical researcher working on nicotinamide riboside.
He has nothing to gain from promoting it but since I (his Mum) have had P.D. since he was just a little fella' he has grown up watching its progression in frustration and anxious for 'something better' for PWP.
In mice they've had some amazing results when they're given it in their water compared to those not given it and he seems genuinely excited for me.
I know its still early days as far as this research goes however I take 500mg of it each morning (it can cause insomnia so mornings are best.)
I don't know how to send links but his boss is Professor David Sinclair at Harvard so if you wish to look up the work being done there and also his youtube talks etc. you can.
My sons work on it is done at UNSW Randwick NSW Australia in the Laboratory for Aging
Regards,
Lee

Hi made it up and badboy99

I don't know how to send links but his boss is Professor David Sinclair at Harvard

Here is a link to Professor Sinclair and his Harvard team: http://www.hms.harvard.edu/agingrese...staff/sinclair .

Here is a link to the UNSW Laboratory for Aging: https://medicalsciences.med.unsw.edu...biology-ageing

Professor Sinclair appears in both of them.

Thanks Lee for sharing. How long have you been taking this and have you noticed any changes, good or bad? Where do you get your nicotinamide riboside, I am wondering if one brand is better than another, there are so many out there!

Lee,
Thank you for sharing I'm sure your very proud of your son.

How did you arrive at the 500 mg dose level?

Thanks Kiwi for the links.
Lurking, I've been taking it for 4 - 5 months.
Changes? Nothing much in how I feel but I've been told I appear more animated and a bit faster in everyday movement.
Mine is marketed as Niagen but there may be others (not sure.)
Thanks Badboy.
Gerry, good question re dosage.
It was written on the bottle but if you google it there are people taking massive doses of it which frankly concerns me.
Some are on 1,2,3 grams a day. I couldn't find any bad news about it and when I queried my son he was (I thought anyway) a bit defensive about it!
But I suppose its still early days.
You're taking resveratrol which is another drug the (the Harvard and UNSW teams) work on too with good results to date.
Regards,
Lee