My husband (75) has been on Rytary for one week. He has had Parkinson's approximately 14 years and had been taking a combination of Stalevo and Carbidopa/Levadopa immediate release for a total of approximately 1100 Levadopa per day. It was initially recommended he take 2 tablets 195 three times per day and 3 tablets at bedtime. The first dose was started about 5PM and he was very dyskinetic and, in fact, barely slept that first night because he was so 'wired'. Though he continued moderately dyskinetic for the next couple of days, he had 'on' time of 4 to 4.5 hours between 5 hour doses. We obtained some 145 capsules and are in the process of trying to get the right combination to maintain smooth distribution. Overall the sleep is much, much improved...deeper and longer. Thinking is clearer and, of course, the 'on' time improvement is tremendous.