It's early days in fighting back on my PD symptoms and during this short time I have tried various forms of targeted B vitamins for PD. When I try supplements I put a lot of importance on first impressions.

It seems that in general B2 as riboflavin-5'-phospate, and then B1 are most important. I started with B2 first, using 100mg of B2 twice a day. Upon first use, the next morning I was able to smell again. I did not know in any what to expect, if anything, so it was a real surprise that I awoke being able to smell. Frankly I didn't know that I couldn't smell before this. I can also feel my feet better too. I have had problems with my feet, especially the right one, as far as feeling goes. I had plantar fascitis in that foot for an extended time, and after some physical therapy that problem was licked but my feeling in that foot, along with blood flow was/is compromised with varicose veins. I've been on B-2 for about 5 days now and these gains continue to solidify. I plan on continuing high dose B2 for the duration. It definitely makes a difference. Ideally I would like to move on to a smaller (30mg) dose, every 5 or 6 hours, like the study. So far I haven't found that size. Here's a link to a study that had great success with it ..
http://www.scielo.br/scielo.php?scri...rm=iso&tlng=en

As for B1, I did some days taking benifotiamine to no avail. There were no discernible changes I could feel. I guess reports are that benfotiamine does not cross the blood brain barrier (BBB). How much difference does that make. Well I wasn't sure it would make much difference. All the cells in your body .. nerves especially need B1, so I was unsure if it made a difference.

Yesterday though I go my first delivery of allithiamine, a version of thiamine (B1) from garlic, that easily crosses the BBB. Last night I noticed that could walk in a straight line. You have no idea what it's like to realize that there is a difference in my balance and direction all the sudden, by just walking to the back door and then up the steps. There is definitely something to using a B1 that crosses the BBB. ** Also I just returned from the mall and my walking and balance are definitely much better .. normal in fact!** My typing is better too, though I still have high reliance on spell check, of course. One dose is not gonna fix that. My typing started to deteriorate over the last year or so and it's been quite frustrating, given that I spend ALL DAY working on computers. I do programming and must write about 20-30 emails a day. I also noticed improved eye focusing ability as well.

As for tremor, if anything it has gotten a little worse, but according to the study on B2 and cutting out red meats (including pork) that will likely come in time. **Right now 12.5mg of prami taken under my tongue helps the tremor a lot.** The link for the study is above.

BTW, trying to get these vitamins in a B complex formula is a waste of time for a few reasons .. first is the dose .. complex B vitamins have these in small does and are usually types that don't absorb well. Second is that if you take a lot of B vitamins all at once the B2 gets depleted right away. B2 is used to transfer the other types of B vitamins into their useable form. They call it a "co-factor" for the other B vitamins. I would say that you should take only a few key B vitamins at a time because of this.

As I'm feeling these changes I'm realizing more and more just how long I've been showing these little symptoms that are markers for PD. I know now more clearly the fight ahead and right now, while it's early, I'm gonna do everything I can to push back. I hope that some of these initial impressions will give others some encouragement to try some of these B vitamins. Best of luck to everyone ..