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NeuroDerm Announces Lifting of FDA Clinical Hold on ND0612, a Subcutaneously Delivere

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Old 05-08-2015, 07:20 PM #1
soccertese soccertese is offline
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Default NeuroDerm Announces Lifting of FDA Clinical Hold on ND0612, a Subcutaneously Delivere
http://www.fiercebiotech.com/press-r...eously-deliver
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lab rat (05-09-2015)

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Old 05-09-2015, 09:12 AM #2
lurkingforacure lurkingforacure is offline
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Default why add carbidopa?
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Originally Posted by soccertese View Post
This is great news, but I don't know why they are adding carbidopa to this? I thought it was added to help preserve the levodopa get past the intestinal tract as well as nausea from the levodopa in the gut, so putting it into a formulation which is subcutaneous doesn't make sense. Am I missing something?
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Old 05-09-2015, 09:24 AM #3
soccertese soccertese is offline
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Default
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Originally Posted by lurkingforacure View Post
This is great news, but I don't know why they are adding carbidopa to this? I thought it was added to help preserve the levodopa get past the intestinal tract as well as nausea from the levodopa in the gut, so putting it into a formulation which is subcutaneous doesn't make sense. Am I missing something?
the enzyme that breaks down l-dopa is also in our tissues, i think especially arteries, arterials, etc.

http://www.pharmacologyweekly.com/ar...kinson-disease


you would think you could just take oral carbidopa.
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