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The mystery of Α-synuclein

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Old 05-13-2015, 12:34 PM #1
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Default The mystery of Α-synuclein
Candesartan (Atacand) is available by prescription for hypertension.

http://gumc.georgetown.edu/news/Unra...ing-its-Course
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Old 05-13-2015, 01:09 PM #2
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Some other brain anti-inflammatories are curcumin, green tea, ginseng, gastrodin, resveratrol, and ginger.

I take all but the ginseng and I have no idea if they are helping or not.
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Palmitoylethanolamide (PEA) Updated 9/21/17.
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Old 05-13-2015, 01:42 PM #3
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Originally Posted by GerryW View Post
Some other brain anti-inflammatories are curcumin, green tea, ginseng, gastrodin, resveratrol, and ginger.

I take all but the ginseng and I have no idea if they are helping or not.
Putting aside this was a rodent study, the key to the research was targeting the newly formed TLR1/2 receptor. Candesartan specifically targets the TLR2 receptors.

Of the anti-inflammatories you suggested: curcumin, green tea polyphenols, and resveratrol have all been clinical shown to target TLR2. Ginseng and ginger are better for targeting TLR4 or TLR6. I'm not sure about gastrodin.
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Old 05-13-2015, 02:01 PM #4
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Putting aside this was a rodent study, the key to the research was targeting the newly formed TLR1/2 receptor. Candesartan specifically targets the TLR2 receptors.

Of the anti-inflammatories you suggested: curcumin, green tea polyphenols, and resveratrol have all been clinical shown to target TLR2. Ginseng and ginger are better for targeting TLR4 or TLR6. I'm not sure about gastrodin.
Still does the job.

"Then Maguire-Zeiss and her team tested a drug, developed by researchers at the University of Colorado, which specifically targets TLR1/2. They also tested the hypertension drug candesartan, which can target TLR2. Both agents significantly reduced inflammation."

In any case, I didn't mean to suggest that the anti-inflammatory properties of these herbs were all solely dependent on targeting TLR. Sorry if I confused you.
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Palmitoylethanolamide (PEA) Updated 9/21/17.
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Old 05-13-2015, 02:17 PM #5
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Still does the job.

"Then Maguire-Zeiss and her team tested a drug, developed by researchers at the University of Colorado, which specifically targets TLR1/2. They also tested the hypertension drug candesartan, which can target TLR2. Both agents significantly reduced inflammation."

In any case, I didn't mean to suggest that the anti-inflammatory properties of these herbs were all solely dependent on targeting TLR. Sorry if I confused you.
Actually, I think I confused you. I was just trying to point out that if this research team is really on to something, and we wanted to try and use a natural approach like you suggested, then some of the supplements may emulate the effect of candesartan more than others. And, I totally agree, most of these supplements target other receptors in addition to TLR. Sorry if I confused you.
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Old 05-14-2015, 04:09 PM #6
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Default a-synuclein
As I read it they have found a way to lessen the response of the cells, TLR 1 and 2. But they do not say what happens to the proteins that are still building up within the brain. Their study only says that it stops or slows the inflammation. What happens to the proteins that are still miss folding?
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Old 05-16-2015, 09:20 PM #7
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Default Brain anti-inflimatories
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Some other brain anti-inflammatories are curcumin, green tea, ginseng, gastrodin, resveratrol, and ginger.

I take all but the ginseng and I have no idea if they are helping or not.
Gerry,
You can try red ginseng from Korea, ginseng is an adaptogen, there is no harm. Ginseng helps to sleep but it's a very good sleep.
Buy red ginseng in a jar, it's the best one. It costs around more than C$40.
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