Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 05-20-2015, 11:01 AM #1
zanpar321 zanpar321 is offline
Member
 
Join Date: Feb 2014
Posts: 365
10 yr Member
zanpar321 zanpar321 is offline
Member
 
Join Date: Feb 2014
Posts: 365
10 yr Member
Default Possible quick blood test to measure Alpha Synuclein Levels

What if there was a fast way to measure alpha synuclein levels using just one drop of blood? Can you imagine going to visit your doc and being able to measure your alpha synuclein misfolding levels in a few minutes? Then the doc could prescribe a dose of drug AlphaSyn Fixer as needed to remove misfolded alpha synuclein in the blood! I believe this will happen in the next 10 years or less!

The immunoassay device in the video could be used to detect alpha synuclein in blood.

https://www.youtube.com/watch?v=jzeFdNXIzOc

Last edited by zanpar321; 05-20-2015 at 11:39 AM.
zanpar321 is offline   Reply With QuoteReply With Quote

advertisement
Old 05-20-2015, 11:26 AM #2
Tupelo3 Tupelo3 is offline
Member
 
Join Date: Mar 2013
Location: New Jersey
Posts: 832
10 yr Member
Tupelo3 Tupelo3 is offline
Member
 
Join Date: Mar 2013
Location: New Jersey
Posts: 832
10 yr Member
Default

Quote:
Originally Posted by zanpar321 View Post
What if there was a fast way to measure alpha synuclein levels using just one drop of blood? Can you imagine going to visit your doc and being able to measure your alpha synuclein levels in a few minutes? Then the doc could prescribe a dose of drug AlphaSyn Reducer as needed to bring the levels down! I believe this will happen in the next 10 years or less!

The immunoassay device in the video could be used to detect alpha synuclein in blood.

https://www.youtube.com/watch?v=jzeFdNXIzOc
Actually, the relationship between cerebral fluid a-syn and PD is negative. People with PD have lower levels, not higher. The thought is that the a-syn is staying in the brain, aggregating as the neurons fail to dispose of them as waste. Keep in mind, it's not the level of a-syn that is thought to be the problem. The theory is it's the mutation into a misfolded form that causes the problem.

http://www.uphs.upenn.edu/news/News_...2013/08/shaw2/
Tupelo3 is offline   Reply With QuoteReply With Quote
Old 05-20-2015, 11:34 AM #3
zanpar321 zanpar321 is offline
Member
 
Join Date: Feb 2014
Posts: 365
10 yr Member
zanpar321 zanpar321 is offline
Member
 
Join Date: Feb 2014
Posts: 365
10 yr Member
Default

Quote:
Originally Posted by Tupelo3 View Post
Actually, the relationship between cerebral fluid a-syn and PD is negative. People with PD have lower levels, not higher. The thought is that the a-syn is staying in the brain, aggregating as the neurons fail to dispose of them as waste. Keep in mind, it's not the level of a-syn that is thought to be the problem. The theory is it's the mutation into a misfolded form that causes the problem.

http://www.uphs.upenn.edu/news/News_...2013/08/shaw2/
Thanks for that info. I did see a similar study which I thought showed lower alpha syn levels for PD patients. Does this mean that the present 2 clinical trials to lower Alpha Synuclein levels won't likely be much help to treat PD?
zanpar321 is offline   Reply With QuoteReply With Quote
Old 05-20-2015, 01:24 PM #4
Tupelo3 Tupelo3 is offline
Member
 
Join Date: Mar 2013
Location: New Jersey
Posts: 832
10 yr Member
Tupelo3 Tupelo3 is offline
Member
 
Join Date: Mar 2013
Location: New Jersey
Posts: 832
10 yr Member
Default

Quote:
Originally Posted by zanpar321 View Post
Thanks for that info. I did see a similar study which I thought showed lower alpha syn levels for PD patients. Does this mean that the present 2 clinical trials to lower Alpha Synuclein levels won't likely be much help to treat PD?
No, that should not be a problem. Prothena has designed their antibody immunotherapy as passive immunization against the C-terminus (CT) truncation of a-syn. CT of a-syn is believed to cause toxic fragments which causes the oligomerization, propagation and aggregation of the a-syn in the neuron. They have shown this to work in-vitro and with mouse induced PD. Now, we need to see if works in humans.

These vaccines are still years away from possible commercialized use, as they move through the clinical trial process. However, if you like the concept, and are comfortable that they are relatively safe (which the data to date has shown) you can go into the phase 2 trial. Prothena will have multiple sites throughout the US. Affiris is only conducting trials in Europe.
Tupelo3 is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
lab rat (05-20-2015), zanpar321 (05-20-2015)
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Too much or too little alpha-synuclein VICTORIALOU Parkinson's Disease 0 03-20-2013 06:50 PM
Alpha-synuclein Diego24 Parkinson's Disease 6 07-14-2012 11:59 PM
Alpha synuclein paula_w Parkinson's Disease 7 08-15-2011 02:57 PM
Blood test back levels ok DiMarie Bipolar Disorder 3 10-28-2009 11:04 PM


All times are GMT -5. The time now is 01:06 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.