NPF advice on how to dose rytary
 

written by HAUSER, who ran a clinical trial on rytary.
http://www.parkinson.org/NationalPar...2ed3d4ab34.pdf
sure sounds like your're getting too much l-dopa.

the same problems arose when controlled release C/L came on the market, figuring out individual doseages after it came on the market. the problem with controlled release C/L is bioavailability can be variable based on gastric emptying, you can end up with too much or too little l-dopa getting into your system. the bioavailability of rytary appears to be lower than CR and add to that the short half life of L-DOPA, potential protein interference, constipation affects, etc it seems highly likely you might get an overdose.

if i was trying rytary i'd start off taking regular C/L for my first dose and an hour later rytary for 2nd dose, then back to regular C/L for the rest of the day after the rytary wore off to get a sense of how long it lasted - try this for a week or longer, then change dose to rytary in the morning, followed only by C/L, then take rytary as my last dose of the day, and then finally switching to RYTARY once I got a feel on how it worked. you might have to always tweak the rytary dosage with some regular C/L?

I am only on C/L, immediate and controlled release, and even then the simple 50/200CR is unpredictable after my first real meal, when I have to absolutely be ON I switch to C/L immediate release for that time period or day and basically eat very little until the evening.