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07-16-2015, 10:31 AM | #1 | ||
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Scientists discover potential treatment for Parkinson's disease
http://medicalxpress.com/news/2015-0...n-disease.html http://www.pnas.org/content/112/28/8756 |
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07-16-2015, 05:36 PM | #2 | ||
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Here's my briefing notes based on the referenced Medical Express article (the PNAS paper is behind a pay-wall):
In a rat model of Parkinson's it was found that: - Nurr1, a protein found in the brain, "protects the brain's ability to generate dopamine neurons"; - activating Nurr1 in rats eliminated all symptoms of Parkinson's. Nurr1 is activated by existing FDA approved anti-malarials, chloroquine and amodiaquine. There would seem to me to be a good case for going ahead with clinical trials on the existing drugs. But no, they want to modify the drugs first, before carrying out clinical trials. Why? Interestingly, there's a lot of claims in PwP sites around the web that quinine relieves PD, and a few claiming that it causes it. John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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07-16-2015, 06:19 PM | #3 | |||
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Grand Magnate
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It looks promising to me.
I have met Petsko (one of the corresponding authors) casually a few times at conferences - he does not publish rubbish.
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Knowledge is power. |
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"Thanks for this!" says: | Betsy859 (07-18-2015), soccertese (07-17-2015) |
07-17-2015, 04:32 AM | #4 | ||
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Plaquenil --aka Hydroxycloroquinine is often given to patients all over the world for auto immune diseases such as Lupus, Sjogren's etc as well as an anti malarial.
You would think that a positive effect on PD would have been evident given the large patient population taking it. There should have been an epidemiological sign of less PD in countries with malaria. Just wondering. |
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"Thanks for this!" says: | badboy99 (07-17-2015), Betsy859 (07-18-2015), BreezyRacer (07-17-2015), lurkingforacure (07-17-2015), olsen (07-19-2015), shcg (07-17-2015), Tupelo3 (07-17-2015) |
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