Parkinson's Disease Tulip


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Old 08-06-2015, 05:36 PM #1
rempatterson rempatterson is offline
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rempatterson rempatterson is offline
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Funny, an MDS told me that the problem with Sinemet losing its effect is due to the progression of the PD. Does anyone here have a research based fact on this subject?

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Originally Posted by Blackfeather View Post
The first neurologist that i went to would not prescribe sinemet as i was 59 years old at the time and according to her sinemet would lose its effectiveness in a few years of use, thereby leaving me without good treatment options at a relative young age for person with parkinson's. My current neurologist won't prescribe it either for the same reason but added that i would likely develop dyskinesia from the use of sinemet at my age. Dyskinesia is a heavy price to pay for a few years of symptom reduction with sinemet use. So it is no wonder that many of us are investigating alternative options. And this is ok. We should not get badgered for this approach by other forum members.
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Old 08-06-2015, 11:11 PM #2
Bogusia Bogusia is offline
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Quote:
Originally Posted by rempatterson View Post
Funny, an MDS told me that the problem with Sinemet losing its effect is due to the progression of the PD. Does anyone here have a research based fact on this subject?
If this was true then “drug holiday” shouldn’t have worked in making Sinemet to be more effective again and yet it did for some PD patients as per this old study http://www.ncbi.nlm.nih.gov/pubmed/7192805
Abruptly stopping or reducing the dose of Sinemet may cause a serious condition called neuroleptic malignant syndrome (NMS) so “drug holidays” are not recommended any more.
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