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Zonisamide for PD

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Old 08-05-2015, 03:27 PM #1
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Default Zonisamide for PD
http://onlinelibrary.wiley.com/doi/1...EBFEB6F.f02t03
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Old 08-05-2015, 10:31 PM #2
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Default What's the problem?
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Originally Posted by lab rat View Post
It's been approved for PD in Japan since 2009. It improves motor and some non-motor symptoms while extending on time. Its side-effect profile is the same as a placebo. It is available now as a cheap generic. Why isn't this being prescribed?
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Old 08-06-2015, 02:07 PM #3
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Default A review of the use of zonisamide in Parkinson's disease
http://www.researchgate.net/publicat...'s_disease

More studies are always warranted. How about calling Japan for their experiences and maybe some prescribing tips?
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Born 1948. Diagnosed 2011. DBS ON 7/17. Taking cd/ld 200 MG at 6 am, 9 am, 12 pm, 3 pm, 6 pm and 9 pm. Finasteride 5 mg, Life Extension Mix and Once-Daily Health Booster, Mitochondrial Energy Optimizer with BioPQQ, Optimized Curcumin (longvida), Triple Action Cruciferous Vegetable Extract with Resveratrol, Vectomega-3, Vit D3 5000U,Lithium orotate 5 mg, AMPK Activator, Kefiran, N-Acetyl-L- Cysteine (NAC), Tri-Magnesium, Advanced NeuroPro, Duozyme,
Palmitoylethanolamide (PEA) Updated 9/21/17.
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Old 08-06-2015, 05:33 PM #4
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I have been on Zonisamide for 5 years. It must help me. I tried going off of it and I got real shaky. So I take one at night. I have been a very slow progresser
Tami
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Old 08-06-2015, 09:28 PM #5
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Default Excellent response to Zonisamide in this patients
Case history of patient with advance PD and levodopa-induced psychotic symptoms helped by Zonisamide

http://onlinelibrary.wiley.com/store...+inconvenience.
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Old 08-07-2015, 07:46 AM #6
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Quote:
Originally Posted by Bogusia View Post
Case history of patient with advance PD and levodopa-induced psychotic symptoms helped by Zonisamide

http://onlinelibrary.wiley.com/store...+inconvenience.
I got a 403 forbidden message.
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Palmitoylethanolamide (PEA) Updated 9/21/17.
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Old 01-08-2017, 08:01 PM #7
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Quote:
Originally Posted by 831Tami View Post
I have been on Zonisamide for 5 years. It must help me. I tried going off of it and I got real shaky. So I take one at night. I have been a very slow progresser
Tami
Can you tell us what your dosage is?
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Old 01-08-2017, 04:57 PM #8
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Default newer studies
Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study
Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study - Murata - 215 - Movement Disorders - Wiley Online Library

Randomized placebo-controlled trial of zonisamide in patients with Parkinson's disease
Randomized placebo-controlled trial of zonisamide in patients with Parkinson's disease - Murata - 215 - Neurology and Clinical Neuroscience - Wiley Online Library
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Born 1948. Diagnosed 2011. DBS ON 7/17. Taking cd/ld 200 MG at 6 am, 9 am, 12 pm, 3 pm, 6 pm and 9 pm. Finasteride 5 mg, Life Extension Mix and Once-Daily Health Booster, Mitochondrial Energy Optimizer with BioPQQ, Optimized Curcumin (longvida), Triple Action Cruciferous Vegetable Extract with Resveratrol, Vectomega-3, Vit D3 5000U,Lithium orotate 5 mg, AMPK Activator, Kefiran, N-Acetyl-L- Cysteine (NAC), Tri-Magnesium, Advanced NeuroPro, Duozyme,
Palmitoylethanolamide (PEA) Updated 9/21/17.
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Old 01-08-2017, 06:02 PM #9
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Wow! Why isn't Fox Foundation and Cure Parkinson's Trust all over this drug?
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Old 01-12-2017, 10:12 AM #10
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Default Zonisamide Discontinued
My wife was on Zonisamide for about 3 years. Her MDS discontinued it a few months ago because we thought it wasn't doing much good. The MDS put her on Rytary which seems to prolong her on times but she still needs about 3 fast relief Sinemet each day. She is well over the equivalent of 1200mg CLD.
She was on low dose naltrexone, LDN, for about 6 years (started 11 years ago) and it did not seem to help. Her PD has advanced to where she has serious hallucinations and delusions. She just started Nuplazid for PD psychosis. She is not a candidate for DBS because of psychosis.
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