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Zonisamide for PD

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Old 08-05-2015, 03:27 PM #1
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Default Zonisamide for PD
http://onlinelibrary.wiley.com/doi/1...EBFEB6F.f02t03
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Old 08-05-2015, 10:31 PM #2
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Default What's the problem?
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Originally Posted by lab rat View Post
It's been approved for PD in Japan since 2009. It improves motor and some non-motor symptoms while extending on time. Its side-effect profile is the same as a placebo. It is available now as a cheap generic. Why isn't this being prescribed?
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Old 08-06-2015, 02:07 PM #3
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Default A review of the use of zonisamide in Parkinson's disease
http://www.researchgate.net/publicat...'s_disease

More studies are always warranted. How about calling Japan for their experiences and maybe some prescribing tips?
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Born 1948. Diagnosed 2011. DBS ON 7/17. Taking cd/ld 200 MG at 6 am, 9 am, 12 pm, 3 pm, 6 pm and 9 pm. Finasteride 5 mg, Life Extension Mix and Once-Daily Health Booster, Mitochondrial Energy Optimizer with BioPQQ, Optimized Curcumin (longvida), Triple Action Cruciferous Vegetable Extract with Resveratrol, Vectomega-3, Vit D3 5000U,Lithium orotate 5 mg, AMPK Activator, Kefiran, N-Acetyl-L- Cysteine (NAC), Tri-Magnesium, Advanced NeuroPro, Duozyme,
Palmitoylethanolamide (PEA) Updated 9/21/17.
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Old 08-06-2015, 05:33 PM #4
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I have been on Zonisamide for 5 years. It must help me. I tried going off of it and I got real shaky. So I take one at night. I have been a very slow progresser
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Old 08-06-2015, 09:28 PM #5
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Default Excellent response to Zonisamide in this patients
Case history of patient with advance PD and levodopa-induced psychotic symptoms helped by Zonisamide

http://onlinelibrary.wiley.com/store...+inconvenience.
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Old 08-07-2015, 07:46 AM #6
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Quote:
Originally Posted by Bogusia View Post
Case history of patient with advance PD and levodopa-induced psychotic symptoms helped by Zonisamide

http://onlinelibrary.wiley.com/store...+inconvenience.
I got a 403 forbidden message.
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Old 08-07-2015, 08:14 AM #7
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Quote:
Originally Posted by GerryW View Post
I got a 403 forbidden message.
If you Google "Effectiveness of zonisamide in a patient with Parkinson's ...
onlinelibrary.wiley.com/doi/10.1111/ncn3.126/pdf"

I am not quite sure why the link won't work, maybe because it is pdf.
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Old 01-08-2017, 03:26 PM #8
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Default Why isn't this being prescribed?
I have read nothing but positive things about zonisamide in PD. I am still mystified about why this isn't being prescribed. I can only presume that it is because it is off patent and available as a generic so drug reps are not pushing it or even just informing neuros of its benefit in PD. It doesn't come up as a treatment option on a search for PD therapies so unless you run across it by accident you are not likely to prescribe it or even know about it.

Has anyone had their doctor suggest it or prescribe it? I am seeing my MDS this week and will see if she is willing to give it a try.
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Born 1948. Diagnosed 2011. DBS ON 7/17. Taking cd/ld 200 MG at 6 am, 9 am, 12 pm, 3 pm, 6 pm and 9 pm. Finasteride 5 mg, Life Extension Mix and Once-Daily Health Booster, Mitochondrial Energy Optimizer with BioPQQ, Optimized Curcumin (longvida), Triple Action Cruciferous Vegetable Extract with Resveratrol, Vectomega-3, Vit D3 5000U,Lithium orotate 5 mg, AMPK Activator, Kefiran, N-Acetyl-L- Cysteine (NAC), Tri-Magnesium, Advanced NeuroPro, Duozyme,
Palmitoylethanolamide (PEA) Updated 9/21/17.
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Old 01-08-2017, 04:57 PM #9
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Default newer studies
Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study
Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study - Murata - 215 - Movement Disorders - Wiley Online Library

Randomized placebo-controlled trial of zonisamide in patients with Parkinson's disease
Randomized placebo-controlled trial of zonisamide in patients with Parkinson's disease - Murata - 215 - Neurology and Clinical Neuroscience - Wiley Online Library
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Born 1948. Diagnosed 2011. DBS ON 7/17. Taking cd/ld 200 MG at 6 am, 9 am, 12 pm, 3 pm, 6 pm and 9 pm. Finasteride 5 mg, Life Extension Mix and Once-Daily Health Booster, Mitochondrial Energy Optimizer with BioPQQ, Optimized Curcumin (longvida), Triple Action Cruciferous Vegetable Extract with Resveratrol, Vectomega-3, Vit D3 5000U,Lithium orotate 5 mg, AMPK Activator, Kefiran, N-Acetyl-L- Cysteine (NAC), Tri-Magnesium, Advanced NeuroPro, Duozyme,
Palmitoylethanolamide (PEA) Updated 9/21/17.
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Old 01-08-2017, 06:02 PM #10
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Wow! Why isn't Fox Foundation and Cure Parkinson's Trust all over this drug?
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