The highest dosage of L-dopa needed was 21,000 mg(or 52,500 mg of mucuna standardized to 40% L-dopa) as stated in this paper - https://neurosupport.files.wordpress...tted-paper.pdf

With your father he could be anywhere throughout the range of 240 mg to 21,000. As you stated it is specific to each individual and the amount of damage that has occurred in the brain. The more damage the more that is needed. Given the fact that your father has severe parkinsons symptoms, he will likely need quite a bit of L-dopa to be able to control it. But you also need to balance it against 5-htp and L-Tyrosine for it to work effectively and control side effects.

Here is a case study of a parkinsons patient treated by Dr. Hinz - https://neurosupport.files.wordpress...-parkinson.pdf

Dr. Stein usually responds pretty quickly to emails so you should get a response soon. If for whatever reason you dont get a email back over the next few days, let me know and I will get in contact with him on your behalf.

Thx alot for help . Yes i read that papers and many others written by dr. Hinz and dr. Stein . And i read also whole of dr. Stein blog too . Will be wait for him reply and will update the results here. The big problem of me is far country of mine to DBS lab ....

Hi Babak,
I know nothing about this alternative treatment or protocol but what concerns me is your disregard of medication that a registered medical practitioner who is familiar with Parkinsons has prescribed.
Please don't stop or reduce it and return to the neurologist for advice.
He needs his Madopar.
If I read it wrongly and he's still on it I'm sorry otherwise go back to neurologist.

Hi ,thx . 2 years ago when my father stop moving anymore , we contacted with his neurologist and he did his best .he added madopar/sifrol dosage , he added clozapine and asentra to my father regim . But the symptoms get worse and worse .... Yes as my case it was end of road . My dad had shown all side effects of carbidopa , his body was empty of B-6 . It seems that the drugs like madopar is acting well for 5-10 years .
At the momment i am glad to start amino acid therapy . He is very better but has far way yet to recover fully.

Ok, Dr. Stein replied me , and he confirmed all of your advices .Anyway I will update users if any success occurred in future.

Just some updates about my father PD:
I continue to Amino acids therapy on my father and adjusting the doses and suddenly at the below dosages many of symptoms disappeared or changed from sever to mild :
-------------------------------------------------------------------------------
L-dopa (Mucuna 98-99 %) = 20.7 grams/Day (6x3.45 grams)
5-HTP= 150 mg /day (3x50 mg)
L-tyrosine = 21.3 grams/Day (6x3.55 grams)
L-Cysteine = 4.5 grams/Day (3x1.5 grams , first dose at noon)
B-6 = 300 mg/day (150mg PLP + 150 mg time released)
others/cofactors :
Vitamin C (1000 mg) , Selenium (400 mcg) , Folate (400 mcg) ,Active B-Complex srt (2 tablets), L-Lysine (500 mg) , B12 (1000 mcg) , Calcium Carbonate (240 mg), NADH (10 mg) , Probiotic Complex (1 capsule)
----------------------------------------------------------------------------------

Symptoms improved are :
- His night sleep problem solved , he sleeps about 8 hours last two nights.
- His mental status is very better.
- He watched TV some hours , (Before He did not)
- He eat a few more foods by mouth , (He is using NG tube about two years)
- Almost No delusions (just about 10 min / day) . Before he have delusions about 3-4 hours per day and all of night time.

Symptoms not changed:
- His physical activity . (its about 2 years that he cant get out from his bed)

I am deciding to increase L-tyrosine dosage in next weeks , and try some minor changes to 5-HTP , But wont touch L-dopa . coz at this point I think L-tyrosine could manage minor L-dopa deficiency.

Any users here who are on this protocol could advices me : After reach to balanced doses , how much time needed to see full benefits of this therapy ?

thx a lot for reading ....
Babak

I am concerned about the amount of tyrosine that you are giving your father.

Its Tolerable Upper Limit is in the range of 0.4-6 g/day. You are giving him, being conservative, about 3.5x that limit and are thinking about giving him even more. Giving him so much tyrosine could well have adverse health consequences.

I strongly suggest that you consult an evidence-based health professional (ideally somebody whose knowledge includes PD) before continuing to medicate your father.

Dear Kiwi ,thank you , please take a look at this publication :
*admin edit*

the link of this pdf is in the post number #46 of this thread .
(I cant copy link yet here)

As noted at this pdf (page 19) , the L-tyrosine dosage in Dr. Hinz protocol is : 375 - 75,750 mg /day
(Table 2: Dosing parameters reported on last lab sample submitted)

Best Wishes

Thank you for the reference to that link. I have read it carefully and am not impressed. Quoting from one of many dubious statements in it:

"Normally, L-tyrosine and L-tryptophan dietary intake provides optimal competitive inhibition balance between dopamine and serotonin precursors with no side effects. However, for proper balance, like force must balance like force. ". The emphases are mine.

The phrase "optimal competitive inhibition balance" sounds very sciencey but it means nothing and "like force must balance like force." sounds like mysticism to me - I doubt that any biomedical scientist (like me) would put much credence on statements like those.

Table 2 in the manuscript covers a very wide (a factor of 200(!)) range of daily tyrosine doses. Nowhere in the manuscript are there any independent clinical accounts of how many patients may have benefited from doses in that very wide range. Until such data are available I don't think that Table 2 says much.

If you want to medicate your father with tyrosine then, in his health interests, please keep well below the Tolerable Upper Limit for it.

How does the statement optimal competitive inhibition balance mean nothing? Competitive inhibition is defined as a form of enzyme inhibition where binding of the inhibitor to the active site on the enzyme prevents binding of the substrate and vice versa. Given that both 5-htp and L-dopa compete for the AADC enzyme(along with histidine and phenylalanine) they are thusly involved in competitive inhibition with each other.

Sources
http://www.ncbi.nlm.nih.gov/pubmed/?...n+regions+rats

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157489/

Full bibliography - http://neurosupport.com/764-2/

I also want to begin to see independent studies on their work, but right now there are none. I do not believe that simply because there are none warrants disbelief in all of their work thus far though. We should be skeptical but not dismissive.

Also what they are doing in the treatment of parkinsons is not that different from the conventional treatment of it. They are still using L-dopa, the only difference is they are not using carbidopa, but rather using 5-htp to control side effects of L-dopa. They also use Tyrosine to control fluctuations in synaptic concentrations of dopamine/serotonin by way of melanin steal. Source - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266417/. As well as L-Cysteine because L-dopa has been show to deplete sulfur amino acids. Along with other co-factors.

In regards to engsecs situation, i mean it really is up to him/her to decide what to do. I think the fact that his/her father has been unable to get out of bed for the last 2 years which was not assisted by conventional treatment, signifies there is no further benefit to be had from that. The father is already beginning to see improvement, in a situation where there is no other treatment to be done that can offer benefit to someone in such a severe condition. So to me, I dont see a reason for objection towards it. What other option does he have? Why not at least try especially when there is evidence to support the validity of it?