Hi all ,
My father is 75 years old and have PD for about 17 years , he was using Madopar and paramapixol (Sifrol) always . About 2 years ago he stop walking , talking , eating ....
and he is in bed from that time , he had very bad condition , his last dosing was : Madopar 200/50 x 6 times a day + 3x.36 mg paramapixol . some months ago I read about amino therapy and grab whole of things needed to start the process , I read almost whole papers created by Dr. Hinz and Dr. Alvin Stein .
I am not in USA , so I forced to do all things by myself . I bought L-dopa (mucuna) , tyrosine , cysteine , b6 , folate , selenium and other cofactors from online shops and start the job .
I cant offer test from DBS lab , so I am monitoring him every hours and decide to what to do.
his current dosage of amino acids are :
L-dopa (99% mucuna - source from usa) = 18.6 Gram per day
L-tyrosine = 12 gram per day
L-cysteine= 4.5 gram per day
5-Htp = 100 mg per day
B6= 300 mg per day
I did a pill stop some days ago and it shows that my father need higher dosage of L-dopa .
His main symptoms are = confusion - agitation - delusions and sleep disorders
I don't know when he will reach to balanced dose. I should mention that his overall condition and symptoms are very better from before starting aminos.
I would like to hear if anyone else here is using higher that this dose of L-dopa .
Best Wishes
Babak

Get in contact with Dr. Stein. I believe he works with patients who are not in the usa. You will not be able to successfully treat your father without doing lab tests to control dopamine fluctuations with tyrosine. Also, you need to be certain the substances you are using are actually what they claim to be. The supplement industry is laden with false labeling which means the tyrosine or 5-htp you are buying may not actually be 100% what they say it is which will make it impossible to treat him correctly.

Dr Steins offices phone # - 954-581-8585 or email him at nobones@aol.com

If you decide to call, do it during the week. They are not open on the weekend.

I repeat do NOT do this on your own. You NEED the lab tests as well as the experience of a trained physician in this approach to be able to do it successfully. Get in contact with Dr. Stein, he does consultations over the phone so you should be able to do it.

I know all this because I am a patient of Dr. Steins for the treatment of TBI related issues.

Hi billboby21 ,
Thx for your idea , i just sent an email to Dr. Stein . Will be wait for him . Anyway i would like to know the Amino dosage of a patient with an over 15 yrs history of PD. Just for compare . Coz all of cases in this forum have a history of PD below 15 yrs. i am know that the dosage will differ for every case , just for compare.

The highest dosage of L-dopa needed was 21,000 mg(or 52,500 mg of mucuna standardized to 40% L-dopa) as stated in this paper - https://neurosupport.files.wordpress...tted-paper.pdf

With your father he could be anywhere throughout the range of 240 mg to 21,000. As you stated it is specific to each individual and the amount of damage that has occurred in the brain. The more damage the more that is needed. Given the fact that your father has severe parkinsons symptoms, he will likely need quite a bit of L-dopa to be able to control it. But you also need to balance it against 5-htp and L-Tyrosine for it to work effectively and control side effects.

Here is a case study of a parkinsons patient treated by Dr. Hinz - https://neurosupport.files.wordpress...-parkinson.pdf

Dr. Stein usually responds pretty quickly to emails so you should get a response soon. If for whatever reason you dont get a email back over the next few days, let me know and I will get in contact with him on your behalf.

Thx alot for help . Yes i read that papers and many others written by dr. Hinz and dr. Stein . And i read also whole of dr. Stein blog too . Will be wait for him reply and will update the results here. The big problem of me is far country of mine to DBS lab ....

Ok, Dr. Stein replied me , and he confirmed all of your advices .Anyway I will update users if any success occurred in future.

Just some updates about my father PD:
I continue to Amino acids therapy on my father and adjusting the doses and suddenly at the below dosages many of symptoms disappeared or changed from sever to mild :
-------------------------------------------------------------------------------
L-dopa (Mucuna 98-99 %) = 20.7 grams/Day (6x3.45 grams)
5-HTP= 150 mg /day (3x50 mg)
L-tyrosine = 21.3 grams/Day (6x3.55 grams)
L-Cysteine = 4.5 grams/Day (3x1.5 grams , first dose at noon)
B-6 = 300 mg/day (150mg PLP + 150 mg time released)
others/cofactors :
Vitamin C (1000 mg) , Selenium (400 mcg) , Folate (400 mcg) ,Active B-Complex srt (2 tablets), L-Lysine (500 mg) , B12 (1000 mcg) , Calcium Carbonate (240 mg), NADH (10 mg) , Probiotic Complex (1 capsule)
----------------------------------------------------------------------------------

Symptoms improved are :
- His night sleep problem solved , he sleeps about 8 hours last two nights.
- His mental status is very better.
- He watched TV some hours , (Before He did not)
- He eat a few more foods by mouth , (He is using NG tube about two years)
- Almost No delusions (just about 10 min / day) . Before he have delusions about 3-4 hours per day and all of night time.

Symptoms not changed:
- His physical activity . (its about 2 years that he cant get out from his bed)

I am deciding to increase L-tyrosine dosage in next weeks , and try some minor changes to 5-HTP , But wont touch L-dopa . coz at this point I think L-tyrosine could manage minor L-dopa deficiency.

Any users here who are on this protocol could advices me : After reach to balanced doses , how much time needed to see full benefits of this therapy ?

thx a lot for reading ....
Babak

I am concerned about the amount of tyrosine that you are giving your father.

Its Tolerable Upper Limit is in the range of 0.4-6 g/day. You are giving him, being conservative, about 3.5x that limit and are thinking about giving him even more. Giving him so much tyrosine could well have adverse health consequences.

I strongly suggest that you consult an evidence-based health professional (ideally somebody whose knowledge includes PD) before continuing to medicate your father.

Dear Kiwi ,thank you , please take a look at this publication :
*admin edit*

the link of this pdf is in the post number #46 of this thread .
(I cant copy link yet here)

As noted at this pdf (page 19) , the L-tyrosine dosage in Dr. Hinz protocol is : 375 - 75,750 mg /day
(Table 2: Dosing parameters reported on last lab sample submitted)

Best Wishes

Thank you for the reference to that link. I have read it carefully and am not impressed. Quoting from one of many dubious statements in it:

"Normally, L-tyrosine and L-tryptophan dietary intake provides optimal competitive inhibition balance between dopamine and serotonin precursors with no side effects. However, for proper balance, like force must balance like force. ". The emphases are mine.

The phrase "optimal competitive inhibition balance" sounds very sciencey but it means nothing and "like force must balance like force." sounds like mysticism to me - I doubt that any biomedical scientist (like me) would put much credence on statements like those.

Table 2 in the manuscript covers a very wide (a factor of 200(!)) range of daily tyrosine doses. Nowhere in the manuscript are there any independent clinical accounts of how many patients may have benefited from doses in that very wide range. Until such data are available I don't think that Table 2 says much.

If you want to medicate your father with tyrosine then, in his health interests, please keep well below the Tolerable Upper Limit for it.