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11-05-2015, 10:59 AM | #1 | ||
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The site that SIM00 referred to also has video's of the PD patients.
They are in Italian with English subscript. The younger patients patients seem much improved. http://www.ultimaedizione.eu/videos-...nts-treatment/ Wonder if you can do this at home? Intramuscular injection. Thiamine sold in vials and insulin injectors, buy online? http://www.ultimaedizione.eu/parkinson-eng/ |
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"Thanks for this!" says: | sim00 (11-05-2015) |
11-05-2015, 02:44 PM | #2 | |||
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sure you can do it at home. In my case, my wife, becomes a nurse for a few minutes. I buy it in pharmacy, and requires a prescription. Remember not to expose it to sunlight, because more is exposed becomes more ineffective. I do not use syringes for insulin, but common 2.5ml syringes.
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Sim00 Born in 1969, diagnosed PD in 2007, first symptoms 2004. DBS in July 2016. |
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11-05-2015, 06:42 PM | #3 | ||
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I had an appointment with my Neuro today and provided him with the info on this thread about thiamine. He was very receptive and he agreed to try it. He told me he uses thiamine as a treatment for some of his patients with dementia. I will be given thiamine early next week. I am looking forward to trying it. Will keep folks posted.
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"Thanks for this!" says: | anagirl (11-06-2015), badboy99 (11-06-2015), lab rat (11-11-2015), sim00 (11-06-2015), soccertese (11-06-2015) |
11-07-2015, 11:06 AM | #4 | ||
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I would strongly suggest that if you go the oral route, try allithiamine, the only thiamine I know of that penetrates the blood brain barrier. It made an IMMEDIATE difference for me at only 50 mg a day. I tried them all benefontiamine, thiamine, etc) and it's the only one that worked and it worked quite well.
For me it was an immediate improvement in balance and coordination. You only have $20 to lose ..
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diagnosed with dystonia. 10 mg seligline |
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11-07-2015, 05:08 PM | #5 | ||
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11-08-2015, 09:27 AM | #6 | ||
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Hi BreezyRacer, could you provide more details on how allithiamine has helped you with your PD?
I started to do a search on allithiamine and PD. It seems to behave as a Prodrug which, from what I can understand, is a molecule that when combined with a med like Sinemet can greatly enhances the ability of L-dopa to cross the BBB. Never heard of prodrugs before but it is interesting and may be a great improvement in the effectiveness of Sinemet, meaning that more L-dopa goes to the brain and less to the body with less side effects. I guess I'll buy some. http://www.sciencedirect.com/science...78517394002716 The plasma levels of DOPA demonstrated no significant differences between DOPA and the prodrugs. In contrast, however, brain levels of DOPA were remarkably elevated following administration of the prodrugs. Among the prodrugs examined, ZiPr-DOPA(P)2 was found to most efficiently facilitate delivery of DOPA to brain and this compound showed 30- and 3.7-fold greater increases in the AUC and MRT of DOPA in brain, respectively, than did DOPA itself. These findings suggest that a redox ring-closure system to a quaternary thiazolium can be used as an alternative chemical delivery system to the brain. http://www.researchgate.net/publication/51790350 Abstract: L-Dopa is the mainstay of Parkinson’s disease therapy; this drug is usually administered orally, but it is extensively metabolized in the gastrointestinal tract, so that relatively little arrives in the bloodstream as intact L-Dopa. The peripheral conversion of L-Dopa by amino acid decarboxylase to dopamine is responsible for the typical gastrointestinal and cardiovascular side effects. To minimize the conversion to dopamine outside the central nervous system, L-Dopa is usually given in combination with peripheral inhibitors of amino acid decarboxylase. In spite of that, other central nervous side effects such as dyskinesia, on-off phenomenon and end-of-dose deterioration still remain. The main factors responsible for the poor bioavailability are the drug’s physical-chemical properties: low water and lipid solubility, resulting in unfavorable partition, and the high susceptibility to chemical and enzymatic degradation. Starting from these considerations the prodrug approach has been applied to L-Dopa in order to overcome its metabolism problems and to improve its bioavailability. The goal of this paper is to provide the reader with a critical overview on L-Dopa prodrugs here classified according to the nature of the main chemical modification on L-Dopa backbone that led to the formation of the desired derivative. http://www.ncbi.nlm.nih.gov/pubmed/15328496 http://www.ncbi.nlm.nih.gov/pubmed/21150770 |
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11-09-2015, 11:49 AM | #7 | ||
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Ashley
My experiences are in this thread below. I should clarify that I do not have PD, though when my symptoms started up, they were very much like PD. It took a long time but I did get to see a really good neurologist, but after much of my symptoms had been taken care of. I was diagnosed with dystonia. There are a lot of studies around the world on PD and B vitamins and those studies led me in the direction of this thread. I have NOT taken Sinemet, either alone or with allithiamine. http://neurotalk.psychcentral.com/thread218079.html In the end I have to say that I had a long term B vitamin deficiency caused by candida overgrowth in my small intestine, likely for over a decade. Since I corrected this core problem and started supplementing with B2 and allithiamine my symptoms greatly improved. I tried other B vitamins as well and they made some difference for a bit but that was likely because a shortage of B2 will shut down the methylation process, which is the conversion process your body goes thru to make a range of B vitamins use-able. BTW a late post on the thread by someone else said that they have to using higher does of allithiamine to great effect for them. I think he/she was diagnosed with PD. You might want to PM them. I hope this helps. And BlackFeather, yes, allithiamine is hard to find. I get mine from Life Extension though it is not made by them. The brand I use is Ecological Formulas.
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diagnosed with dystonia. 10 mg seligline |
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"Thanks for this!" says: | moondaughter (12-20-2018) |
12-26-2018, 06:30 PM | #8 | ||
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I am taking orally Life Extension brand Mega Benfotiamine (B1) 250mg 2x a day plus R Alpha Lipoic Acid 100mg 2x a day and B12 300 mcg .
With these Vitamins and my DBS, I feel "normal". I am trying to reverse or slow down the natural degeneration of PDby regenerating my nervous system. My family has noticed a remarkable improvement. There is a product out there that combines all called nerve renew. |
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12-27-2018, 07:53 AM | #9 | |||
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Smooth seas do not make skillful sailors.... Nature loves courage. “The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.” ~ Nikola Tesla |
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"Thanks for this!" says: | Betsy859 (02-20-2019) |
12-27-2018, 10:17 AM | #10 | ||
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I can't help but notice the date on this article, and while it's great that this work was done, am frustrated at the lack of progress on pursuing it further. Makes me crazy
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"Thanks for this!" says: | Betsy859 (02-20-2019) |
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