Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 11-07-2015, 11:06 AM #11
BreezyRacer BreezyRacer is offline
Member
 
Join Date: Mar 2015
Posts: 116
8 yr Member
BreezyRacer BreezyRacer is offline
Member
 
Join Date: Mar 2015
Posts: 116
8 yr Member
Default

I would strongly suggest that if you go the oral route, try allithiamine, the only thiamine I know of that penetrates the blood brain barrier. It made an IMMEDIATE difference for me at only 50 mg a day. I tried them all benefontiamine, thiamine, etc) and it's the only one that worked and it worked quite well.

For me it was an immediate improvement in balance and coordination. You only have $20 to lose ..
__________________
diagnosed with dystonia.
10 mg seligline
BreezyRacer is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
anagirl (11-07-2015), eds195 (11-07-2015), moondaughter (12-20-2018), sim00 (11-07-2015)

advertisement
Old 11-07-2015, 05:08 PM #12
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
8 yr Member
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
8 yr Member
Default

Quote:
Originally Posted by BreezyRacer View Post
I would strongly suggest that if you go the oral route, try allithiamine, the only thiamine I know of that penetrates the blood brain barrier. It made an IMMEDIATE difference for me at only 50 mg a day. I tried them all benefontiamine, thiamine, etc) and it's the only one that worked and it worked quite well.

For me it was an immediate improvement in balance and coordination. You only have $20 to lose ..
I have tried to find allithiamine locally, to no avail. I will have to order it. I am looking at trying 100mg thiamine injection protocol. Are you thinking oral route is better? Certainly less painfull and easier.
Blackfeather is offline   Reply With QuoteReply With Quote
Old 11-08-2015, 09:27 AM #13
ashleyk ashleyk is offline
Member
 
Join Date: Oct 2006
Location: New England
Posts: 262
15 yr Member
ashleyk ashleyk is offline
Member
 
Join Date: Oct 2006
Location: New England
Posts: 262
15 yr Member
Default Allithiamine

Hi BreezyRacer, could you provide more details on how allithiamine has helped you with your PD?
I started to do a search on allithiamine and PD. It seems to behave as a Prodrug which, from what I can understand, is a molecule that when combined with a med like Sinemet can greatly enhances the ability of L-dopa to cross the BBB.
Never heard of prodrugs before but it is interesting and may be a great improvement in the effectiveness of Sinemet, meaning that more L-dopa goes to the brain and less to the body with less side effects. I guess I'll buy some.

http://www.sciencedirect.com/science...78517394002716

The plasma levels of DOPA demonstrated no significant differences between DOPA and the prodrugs. In contrast, however, brain levels of DOPA were remarkably elevated following administration of the prodrugs. Among the prodrugs examined, ZiPr-DOPA(P)2 was found to most efficiently facilitate delivery of DOPA to brain and this compound showed 30- and 3.7-fold greater increases in the AUC and MRT of DOPA in brain, respectively, than did DOPA itself. These findings suggest that a redox ring-closure system to a quaternary thiazolium can be used as an alternative chemical delivery system to the brain.

http://www.researchgate.net/publication/51790350

Abstract: L-Dopa is the mainstay of Parkinson’s disease therapy; this drug is usually administered orally, but it is extensively metabolized
in the gastrointestinal tract, so that relatively little arrives in the bloodstream as intact L-Dopa. The peripheral conversion of L-Dopa
by amino acid decarboxylase to dopamine is responsible for the typical gastrointestinal and cardiovascular side effects. To minimize the
conversion to dopamine outside the central nervous system, L-Dopa is usually given in combination with peripheral inhibitors of amino
acid decarboxylase. In spite of that, other central nervous side effects such as dyskinesia, on-off phenomenon and end-of-dose deterioration
still remain. The main factors responsible for the poor bioavailability are the drug’s physical-chemical properties
: low water and lipid
solubility, resulting in unfavorable partition, and the high susceptibility to chemical and enzymatic degradation. Starting from these considerations
the prodrug approach has been applied to L-Dopa in order to overcome its metabolism problems and to improve its bioavailability.
The goal of this paper is to provide the reader with a critical overview on L-Dopa prodrugs here classified according to the nature
of the main chemical modification on L-Dopa backbone that led to the formation of the desired derivative.

http://www.ncbi.nlm.nih.gov/pubmed/15328496
http://www.ncbi.nlm.nih.gov/pubmed/21150770
ashleyk is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
anagirl (11-08-2015), Bogusia (11-08-2015), eds195 (11-08-2015), moondaughter (12-26-2018)
Old 11-09-2015, 11:49 AM #14
BreezyRacer BreezyRacer is offline
Member
 
Join Date: Mar 2015
Posts: 116
8 yr Member
BreezyRacer BreezyRacer is offline
Member
 
Join Date: Mar 2015
Posts: 116
8 yr Member
Default

Ashley

My experiences are in this thread below. I should clarify that I do not have PD, though when my symptoms started up, they were very much like PD. It took a long time but I did get to see a really good neurologist, but after much of my symptoms had been taken care of. I was diagnosed with dystonia.

There are a lot of studies around the world on PD and B vitamins and those studies led me in the direction of this thread. I have NOT taken Sinemet, either alone or with allithiamine.

http://neurotalk.psychcentral.com/thread218079.html

In the end I have to say that I had a long term B vitamin deficiency caused by candida overgrowth in my small intestine, likely for over a decade. Since I corrected this core problem and started supplementing with B2 and allithiamine my symptoms greatly improved. I tried other B vitamins as well and they made some difference for a bit but that was likely because a shortage of B2 will shut down the methylation process, which is the conversion process your body goes thru to make a range of B vitamins use-able.

BTW a late post on the thread by someone else said that they have to using higher does of allithiamine to great effect for them. I think he/she was diagnosed with PD. You might want to PM them.

I hope this helps.

And BlackFeather, yes, allithiamine is hard to find. I get mine from Life Extension though it is not made by them. The brand I use is Ecological Formulas.
__________________
diagnosed with dystonia.
10 mg seligline
BreezyRacer is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
moondaughter (12-20-2018)
Old 01-29-2016, 04:36 PM #15
VICTORIALOU's Avatar
VICTORIALOU VICTORIALOU is offline
Member
 
Join Date: Oct 2010
Location: Los Angeles area
Posts: 241
10 yr Member
VICTORIALOU VICTORIALOU is offline
Member
VICTORIALOU's Avatar
 
Join Date: Oct 2010
Location: Los Angeles area
Posts: 241
10 yr Member
Default to Blackfeather

Quote:
Originally Posted by Blackfeather View Post
I had an appointment with my Neuro today and provided him with the info on this thread about thiamine. He was very receptive and he agreed to try it. He told me he uses thiamine as a treatment for some of his patients with dementia. I will be given thiamine early next week. I am looking forward to trying it. Will keep folks posted.

Hello Blackfeather

I am very curious about your experience with injectable Thiamine. Did you begin them back in November? I have a friend that will begin treatment injections next week. For the last 2 weeks I have been taking 100 mg of allithiamine and I'm cautiously hopeful.
Thanks
Victoria
__________________
VictoriaLou
.
VICTORIALOU is offline   Reply With QuoteReply With Quote
Old 12-16-2018, 05:53 PM #16
moondaughter's Avatar
moondaughter moondaughter is offline
Member
 
Join Date: Jul 2010
Location: rural Eastern Oregon
Posts: 613
10 yr Member
moondaughter moondaughter is offline
Member
moondaughter's Avatar
 
Join Date: Jul 2010
Location: rural Eastern Oregon
Posts: 613
10 yr Member
Default

Quote:
Originally Posted by VICTORIALOU View Post
Hello Blackfeather

I am very curious about your experience with injectable Thiamine. Did you begin them back in November? I have a friend that will begin treatment injections next week. For the last 2 weeks I have been taking 100 mg of allithiamine and I'm cautiously hopeful.
Thanks
Victoria

I'm curious to know if anyone here is still taking thiamine and if so how much.

Thanks,
MD
__________________
Smooth seas do not make skillful sailors....
Nature loves courage.


“The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.”
~ Nikola Tesla
moondaughter is offline   Reply With QuoteReply With Quote
Old 12-17-2018, 11:21 AM #17
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
8 yr Member
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
8 yr Member
Default

Quote:
Originally Posted by moondaughter View Post
I'm curious to know if anyone here is still taking thiamine and if so how much.

Thanks,
MD
A lot of folks on Health Unlocked PD forum seem to be having very favorable response to Thiamine, mostly in pill form. Some are using thiamine injections. I tried thiamine injections 3 times and felt worse. It made me tired, irritable and with a headache each time it was given. I gave up on it. I tried high dose thiamine supplements for 3 months and never saw any improvement. Though lately I'm thinking of giving another try. As for injections, I understand they sometimes use aluminum as a stabilizer/preservatives in in injectable liquid thiamine. Maybe that is the reason I found it intolerable.
Blackfeather is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
eds195 (12-17-2018), moondaughter (12-17-2018)
Old 12-18-2018, 02:24 PM #19
moondaughter's Avatar
moondaughter moondaughter is offline
Member
 
Join Date: Jul 2010
Location: rural Eastern Oregon
Posts: 613
10 yr Member
moondaughter moondaughter is offline
Member
moondaughter's Avatar
 
Join Date: Jul 2010
Location: rural Eastern Oregon
Posts: 613
10 yr Member
Default

Quote:
Originally Posted by ashleyk View Post
Worth trying for 6 mo's? Recommended dose up to 400 mg day.
Certainly a lot of information- but , I read your post to say you hesitate to try it yourself...would you care to share your concerns Ashley? For me I feel a bit reserved because it seems to me that whenever people get into micromanagement of symptoms especially with chemistry eventually other imbalances develop that lands a person deeper in a negative feedback loop. Having said that I rely heavily on a couple of supplements targeted at specific symptoms and am very very grateful for their efficacy.

Kind Regards,
MD
__________________
Smooth seas do not make skillful sailors....
Nature loves courage.


“The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.”
~ Nikola Tesla
moondaughter is offline   Reply With QuoteReply With Quote
Old 12-21-2018, 12:32 PM #20
lurkingforacure lurkingforacure is offline
Senior Member
 
Join Date: Feb 2008
Posts: 1,485
15 yr Member
lurkingforacure lurkingforacure is offline
Senior Member
 
Join Date: Feb 2008
Posts: 1,485
15 yr Member
Default We saw no changes:(

Well, we tried this several years ago and noticed not one bit of change. The hardest part was finding a doctor willing to script it, because our neuro was unwilling for whatever reason.

It isn't easy to stab yourself (or loved one) with these B1 injections day after day after day, so if you're going to try this, you might want to get mentally prepared!
lurkingforacure is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
lab rat (12-24-2018), moondaughter (12-21-2018), soccertese (12-24-2018)
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
(Pilot Study) Long-Term Use of Thiamine Injections Reverses Parkinson's Symptoms curem Parkinson's Disease 0 10-28-2015 12:43 PM
Repeated-Dose Oral N-acetylcysteine for the Treatment of Parkinson's Disease badboy99 Parkinson's Disease 8 08-09-2014 09:59 AM
Mestinon high dose long term StephC Myasthenia Gravis 8 01-18-2013 11:24 PM


All times are GMT -5. The time now is 02:02 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.