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01-25-2016, 04:55 PM | #1 | ||
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An epidemiological analysis of traffic related air pollution in Denmark implicates NO2 in Parkinson's: a 27% increase in reported cases of PD in the top quartile compared to the bottom quartile[1].
As a sanity check suggesting causality, in vitro analysis shows NO2 radical increases the rate of alpha-synuclein aggregation [2]. References: [1] "Traffic-Related Air Pollution and Parkinson’s Disease in Denmark: A Case–Control Study" Beate Ritz, Pei-Chen Lee, Johnni Hansen, Christina Funch Lassen, Matthias Ketzel, Mette Sørensen, and Ole Raaschou-Nielsen Environmental Health Perspectives, July 2015 http://ehp.niehs.nih.gov/wp-content/...09313.acco.pdf [2] "Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical." Christopher Andrekopoulos, Hao Zhang, Joy Joseph, Shasi Kalivendi, and B Kalyanaraman Biochem J. 2004 Mar 1; 378(Pt 2): 435–447. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223984/ John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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"Thanks for this!" says: | lindylanka (04-10-2016), Niggs (01-26-2016) |
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