Parkinson's Disease Tulip

Reply
 
Thread Tools Display Modes
Old 03-03-2016, 05:50 PM #1
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
5 yr Member
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
5 yr Member
Default Mannitol disolves Alpha Synuclein

Listen to an interview with Don McCammon and reversal of PD symptoms. I found this info incredibly hopeful. He is a fellow parkie. maybe someone else can post some science links for mannitol and Parkinson's.

http://www.blogtalkradio.com/parkins...insons-disease
Blackfeather is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
aquario (03-03-2016), GerryW (12-23-2016), johnt (03-05-2016), OlliePop (03-14-2016)
Old 03-03-2016, 06:18 PM #2
kiwi33's Avatar
kiwi33 kiwi33 is offline
Magnate
Community Welcome Team
 
Join Date: Jan 2015
Location: Sydney, Australia.
Posts: 2,814
5 yr Member
kiwi33 kiwi33 is offline
Magnate
Community Welcome Team
kiwi33's Avatar
 
Join Date: Jan 2015
Location: Sydney, Australia.
Posts: 2,814
My Mood: Mannitol disolves Alpha Synuclein
5 yr Member
Default

Here is a free-access link about this; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682557/.

Although the work was done using fly and mouse models, this looks encouraging to me.
__________________
Knowledge is power.
kiwi33 is offline   Reply With QuoteReply With Quote
Old 03-04-2016, 03:21 PM #3
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
5 yr Member
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
5 yr Member
Default

Thanks for the link, Kiwi. I thought info on mannitol would elicit more response. I received my order of syncolein and will give it a try.
Blackfeather is offline   Reply With QuoteReply With Quote
Old 03-04-2016, 09:19 PM #4
MartyC MartyC is offline
New Member
 
Join Date: Sep 2015
Posts: 5
3 yr Member
MartyC MartyC is offline
New Member
 
Join Date: Sep 2015
Posts: 5
3 yr Member
Default

Quote:
Originally Posted by Blackfeather View Post
Thanks for the link, Kiwi. I thought info on mannitol would elicit more response. I received my order of syncolein and will give it a try.
Very interesting, please keep us posted on how it treats you Blackfeather.
MartyC is offline   Reply With QuoteReply With Quote
Old 03-05-2016, 08:00 AM #5
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,042
10 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,042
10 yr Member
Default

Is the regimen safe in the long-term?: NOT PROVEN. As I understand it, mannitol needs to be taken daily at a dose of 1.5 tablespoons/day for life. The same research group describe mannitol as a BBB disrupter. There must be a concern as to what this lets into the brain. Against that is its successful long-term use as a food agent.

An interesting claim for mannitol is that its effects can be noticed in two months. (I was expecting a disease progression slowing therapy, such as alpha-synuclein cleansing, to take at least a year before having a noticeable effect.) This shortens the test period. It can be made quicker still by testing continuously throughout the trial: stopping early if the initial results make it unlikely that the positive outcome is achievable; reporting early if the initial results are particularly good. The tap-test can be used for this.

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
johnt is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
aquario (03-05-2016), GerryW (12-23-2016), lab rat (12-20-2016), MartyC (03-05-2016)
Old 03-14-2016, 04:03 PM #6
gerrysawyer8 gerrysawyer8 is offline
New Member
 
Join Date: Feb 2016
Posts: 1
3 yr Member
gerrysawyer8 gerrysawyer8 is offline
New Member
 
Join Date: Feb 2016
Posts: 1
3 yr Member
Default updates on syncolein usage?

Quote:
Originally Posted by Blackfeather View Post
Thanks for the link, Kiwi. I thought info on mannitol would elicit more response. I received my order of syncolein and will give it a try.
Dear Blackfeather, any changes in condition since the use of syncolein? I am wanting to buy for my husband, but don't want to go thru expense if it doesn't work.

Thank you!

Gerry
gerrysawyer8 is offline   Reply With QuoteReply With Quote
Old 03-14-2016, 06:10 PM #7
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
5 yr Member
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
5 yr Member
Default

I am on day 12 and so far don't notice any difference. I am hoping I will experience something positive in the next 2 weeks. I am on board with taking syncolein until I use up my 2 month supply. I'll let everyone know my results.
Blackfeather is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
anagirl (03-14-2016)
Old 03-14-2016, 09:47 PM #8
zanpar321 zanpar321 is offline
Member
 
Join Date: Feb 2014
Posts: 364
5 yr Member
zanpar321 zanpar321 is offline
Member
 
Join Date: Feb 2014
Posts: 364
5 yr Member
Default

Quote:
Originally Posted by Blackfeather View Post
I am on day 12 and so far don't notice any difference. I am hoping I will experience something positive in the next 2 weeks. I am on board with taking syncolein until I use up my 2 month supply. I'll let everyone know my results.
I'm taking the straight mannitol now at at day 8. Some extra gas but not too bad. No improvement yet but will let everyone know how it goes.
zanpar321 is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
anagirl (03-15-2016)
Old 03-17-2016, 02:42 PM #9
ashleyk ashleyk is offline
Member
 
Join Date: Oct 2006
Location: New England
Posts: 242
10 yr Member
ashleyk ashleyk is offline
Member
 
Join Date: Oct 2006
Location: New England
Posts: 242
10 yr Member
Default What to think?

So since Don's email address is posted in this thread, I thought I would ask some Mannitol questions in an email to him.

Here are my questions to Don McCammon:
Can I ask how long you have had PD and if you take Sinemet now or in the past and if it helped you? Is your brother taking mannitol and how has he done on it. And, in general, how have other people who take mantitol done. If some one who has advanced PD, will mannitol allow them to lower their Sinemet dose and also reduce on/off time and other PD problems? Testimonials would be great.

And his reply:
I am so sorry about your wife's condition. At this point I doubt she would benefit from Mannitol in that she has probably lost most if not all of her dopinergic neurons.


Don

So he has not provided any information or testimonials on his customers who he sells Mannitol to. I don't know if he ever took Sinemet and he claims it only helps with early onset PD. I was hoping for a more informative response.
When low dose naltrexone LDN was being claimed as a lifesaver 10 years ago. My wife began taking it then for 7 years. It did not help and she is at a very advanced PD stage now.
ashleyk is offline   Reply With QuoteReply With Quote
Old 03-17-2016, 06:18 PM #10
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
5 yr Member
Blackfeather Blackfeather is offline
Member
 
Join Date: Jun 2014
Posts: 175
5 yr Member
Default

I'm sorry about your frustration with Don. Those are reasonable questions and deserved a response. I asked if syncolein could help with dystonia. He said, "I have no idea". That is all had to say. It's still worth try in my opinion
Blackfeather is offline   Reply With QuoteReply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Can Alpha Synuclein be seen using a microscope? zanpar321 Parkinson's Disease 13 05-20-2015 11:17 AM
Too much or too little alpha-synuclein VICTORIALOU Parkinson's Disease 0 03-20-2013 06:50 PM
Alpha-synuclein Diego24 Parkinson's Disease 6 07-14-2012 11:59 PM
Alpha synuclein paula_w Parkinson's Disease 7 08-15-2011 02:57 PM
Alpha synuclein news lurkingforacure Parkinson's Disease 0 11-05-2008 05:08 PM


All times are GMT -5. The time now is 01:40 AM.

Powered by vBulletin • Copyright ©2000 - 2020, Jelsoft Enterprises Ltd.
Search Engine Optimisation provided by DragonByte SEO v2.0.31 (Lite) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.