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03-04-2016, 07:04 AM
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Levodopa can pass through the BBB into the brain. Can it pass out of the brain unaltered?
John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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| "Thanks for this!" says: | VICTORIALOU (03-04-2016) |
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03-04-2016, 08:37 AM
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#2 | ||
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Quote:
My first thought is: Is all the L.dopa converted, I suspect not. If so where can/ does it go if anywhere. What's your thought on this John ? Nigel |
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| "Thanks for this!" says: | johnt (03-05-2016) |
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03-05-2016, 02:58 AM
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#3 | |||
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Grand Magnate
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Levodopa is transported across the blood-brain barrier by a protein called LAT-1 (L or Large amino acid transporter) This transport protein operates by what is called facilitated diffusion.
What that means is that if the concentration of levodopa outside the brain is high compared to the concentration inside, transport will from outside to inside. On the other hand, if the concentration of levodopa outside the brain is low compared to the concentration inside, transport will probably be from inside to outside.
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Can levodopa pass out of the brain?
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