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04-27-2016, 11:44 AM | #1 | ||
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09-08-2016, 09:15 AM | #2 | ||
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While we wait, forever, for clinical trials to succeed, maybe Curcumin at about 2 grams a day could clear out a-Synclein in PD and Alzheimer's.
PLOS ONE: Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice
For example, there is evidence that α-synuclein aggregates undergo nitration-based oxidative damage [36]. Curcumin is known to be a potent anti-oxidant and may be modulating α-synuclein, and ultimately motor behavior, by decreasing reactive oxygen species [11]. While further studies are needed to better understand the molecular mechanisms underlying chronic curcumin diet intervention in synucleinopathy mouse models, our data demonstrate improvements in motor behavior, providing strong support for curcumin therapy as the subject of further pre-clinical studies. |
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"Thanks for this!" says: | anagirl (09-08-2016), eds195 (09-08-2016), GerryW (09-09-2016), johnt (09-08-2016), Nan Cyclist (09-08-2016) |
09-08-2016, 10:26 AM | #3 | ||
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Ashleyk writes "While we wait, forever, for clinical trials to succeed, maybe Curcumin at about 2 grams a day could clear out a-Synclein in PD and Alzheimer's".
The situation with curcumin is part of the same old problem: a substance that may be a useful therapy, that is probably safe, with some data in its favour, but not enough human, clinical trial data to be definitive. It may be that whether it works will never be known because it offers insufficient profits for anyone to do a proper clinical trial. There are dangers in taking a substance that is not properly tested. But there are also dangers, the lost benefit, the relentless progression of PD, in not taking a substance that may be efficacious. The issue is to get the balance right. The way forward, as I see it, is to get Parkinson's experts to say, based on their theoretical knowledge, animal test results and limited human data, what unproven therapies they would take if they had PD. PwP would choose whether to take the promising therapies, taking into account their relative risks. Their response to the new potential therapies would be monitored. The fastest response should come from Parkinson's experts who have PD. It would be useful to know what non-approved therapies they take. If they are prepared to be open about this, we could have many new potential therapies to consider within a month. John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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"Thanks for this!" says: | badboy99 (09-08-2016), eds195 (09-08-2016), GerryW (09-09-2016), hercules957 (10-18-2017), lab rat (09-08-2016), moondaughter (09-09-2016), soccertese (09-09-2016) |
09-09-2016, 08:58 AM | #4 | |||
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Quote:
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Smooth seas do not make skillful sailors.... Nature loves courage. “The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.” ~ Nikola Tesla Last edited by moondaughter; 09-10-2016 at 07:49 AM. |
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10-09-2017, 11:03 AM | #5 | ||
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It's been about a year since this thread on curcumin appeared. Has anyone been using curcumin and what is your opinion on its effect? Note that it is important that a bio-avaiiable form of curcumin should be used for better absorption and that the half life is in hours so twice daily dosage is needed.
Effect of curcumin analogs onα-synuclein aggregation and cytotoxicity Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate. - PubMed - NCBI Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century Supplement: Curcumin – the #1 anti-cancer spice | BisforBananasCisforCancer Curcumin: The Spice That Can Potentially Help Your Health |
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10-10-2017, 09:19 AM | #6 | ||
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I started taking Longvida Optimised Curcumin 500mg once a day. It says on the bottle that it is "high absorbtion, free form." This was just a couple of weeks ago. I started with 1 capsule a day to see if my stomach can tolerate it and so far I am ok with that. I will increase it to 2 pills a day. I don't see how it could hurt. Put another way, I am willing to risk it. Thanks for the post.
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11-07-2017, 02:17 AM | #7 | ||
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Thanks for the informative post!
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11-08-2017, 12:10 PM | #8 | ||
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JohnT makes valid points about curcumin and possible negative effects. And that we can't be sure of it's benefits, or not, until clinical trials are made. This is all true but who can wait years for the results on a "drug" that drug companies can't make money on?
I remember reading somewhere that in India, tumeric - curcumin is widely used by the population. And that their PD rate is 1/10 that of western countries. |
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