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06-17-2016, 09:43 AM | #1 | ||
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N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data
Compared to controls, the patients receiving NAC had improvements of 4-9 percent in dopamine transporter binding and also had improvements in their UPDRS score of about 13 percent. PLOS ONE: N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data |
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06-17-2016, 09:45 AM | #2 | ||
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06-17-2016, 11:46 AM | #3 | |||
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Life Extension Mix, which I have taken for years, has a daily dose of 600 mg of NAC. Maybe that isn't enough or maybe a 13% improvement isn't noticeable given the vagaries of daily PD symptoms.
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Born 1948. Diagnosed 2011. DBS ON 7/17. Taking cd/ld 200 MG at 6 am, 9 am, 12 pm, 3 pm, 6 pm and 9 pm. Finasteride 5 mg, Life Extension Mix and Once-Daily Health Booster, Mitochondrial Energy Optimizer with BioPQQ, Optimized Curcumin (longvida), Triple Action Cruciferous Vegetable Extract with Resveratrol, Vectomega-3, Vit D3 5000U,Lithium orotate 5 mg, AMPK Activator, Kefiran, N-Acetyl-L- Cysteine (NAC), Tri-Magnesium, Advanced NeuroPro, Duozyme, Palmitoylethanolamide (PEA) Updated 9/21/17. |
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06-17-2016, 12:01 PM | #4 | ||
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According to this image, 13% should be noticeable!
https://images.sciencedaily.com/2016..._1_540x360.jpg |
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"Thanks for this!" says: | GerryW (06-17-2016) |
06-17-2016, 12:02 PM | #5 | ||
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I need to bump my intake from 1x to 2x daily.
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06-17-2016, 04:25 PM | #6 | ||
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06-17-2016, 08:29 PM | #7 | ||
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The results from this trial appear to be very good. But:
- the sample size is very small (12 in the NAC group, 11 in the control group, see Table 1); - the trial is not blinded, and the size of the reported improvement is similar to the placebo effect reported in other studies; - the confounding issues of gender, age and C/L use possibly favour the NAC result. Still, the results are encouraging enough to justify a more powerful trial quickly. In the meantime, it may be worth taking NAC as a "therebo" (possible THERapy or placEBO). John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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06-19-2016, 08:41 PM | #8 | ||
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Hi, I have been taken NAC (Free Form) for more than a year and I should say it made me feel some improvement at least in tremor and overall stable. At very beginning I started with 600 mg per day, then, as I read the articles and reports which suggest that for PWP should take 2,400 mg per day in order to see therapeutic effect. I gradually built the dosage. When I hit 1,200 mg per day, my tremor was reduced noticeably. But, when I hit 2,400 mg per day, severe and very painful constipation came. Because of the bad constipation, I quitted NAC for two weeks and now go back to the starting point of 600 mg. Anyone has the similar experience that can better deal with the constipation caused by NAC in large dosage? Or, the dosage itself is questionable at 2,400 mg? Another side effect is running nose, but that is quite easier to deal with... |
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06-26-2016, 12:43 PM | #9 | ||
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N-Acetylcysteine for Neuroprotection in Parkinson's Disease | Smart Patients
This an interesting trial of phase 1 and2 testing nac and PD. If this trial began in 2012 and lasts 30 days, why does the trial conclude in July 2016? |
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06-27-2016, 08:11 AM | #10 | |||
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although the trial for each subject lasts only 30 days, and the number of subjects required took a year or two to recruit. This allows the researchers to begin the 30-day trial for each subject as soon as they are recruited. That, plus the time needed for trouble-shooting data aquisition and processing of each subject's data could easily take 2 or 3 years.
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