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06-19-2016, 08:12 AM | #1 | ||
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Senior Member
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A recent paper by Cassani et al. [1] has a lot of interesting information on mucuna pruriens (MP). Highlights:
- median levodopa concentration in dried mucuna seeds was 5.29% - given the lack of a DDCI (e.g carbidopa) in MP, for a given amount of levodopa, the area under the curve of plasma levels against time is 3.5 times higher for C/L than for MP. Reference [1] "Mucuna pruriens for Parkinson's disease: Low-cost preparation method, laboratory measures and pharmacokinetics profile" Erica Cassani et al. Journal of the Neurological Sciences, June 15, 2016 http://www.jns-journal.com/article/S...183-6/fulltext John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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"Thanks for this!" says: | Bogusia (06-19-2016), eds195 (06-19-2016), GerryW (06-20-2016), lab rat (06-19-2016), soccertese (06-19-2016) |
06-19-2016, 09:27 AM | #2 | ||
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Magnate
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thanks johnt, very interesting article. much more readable if you download it.
4 patients, longest duration of disease was 2 years, L-DOPA daily intake was 300-475mg. all 4 patients had already been taking mucana, 3 using a prep from an italian pharmacy and i 1 using just mucana they personally obtained. MUCANA is being investigated as an alternative to C/L in countries where C/L is unaffordable. What i noticed is mucana L-DOPA concentration is very variable if you just buy the unprepared "flour". i think there already is evidence that MUCANA can alleviate pd symptoms, i wonder how much is actually being grown in 3rd world countries because there are more productive crops for animal feed which i assume that is the primary use of the plant, i doubt much is grown for human consumption primarily because of the L-DOPA content. just guessing here. i apologize if i'm wrong. |
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06-28-2016, 08:48 AM | #3 | |||
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Senior Member
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I use Zandopa..I knew very little about it when I decided to try it..There was a red spoon in the container..I filled it up to the top level..I was almost symptom less for 6 hours..Then it wore off It was so fast that it felt like turning off a light switch..Now you're on..Now you're off
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