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08-02-2016, 06:46 PM | #1 | ||
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THIS IS HUGE-- May be first drug therapy to alter progression of disease in PD
New Study- reaffirming the gut-brain connection Quantifying rigidity of Parkinson's disease in relation to laxative treatment: a service evaluation -- British Journal of Clinical Pharmacology- -Volume 82, Issue 2;August 2016:441-450-Wiley Online Library Conclusion from authors- "The immediate therapeutic implication is that maintenance laxatives are disease-modifying in PD. " Facts- Bad belly-especially constipation-worse PD symptoms Multiple reports of antibiotics resulting in worsening PD symptoms-often irreversible Study Specifics-Retrospective (79 patients)- London- with rigidity scores looked at approx 10 years before and 10 years after laxatives -- very strong association between beginning laxatives-- first fiber or osmotic (eg Miralex) -if not effective novel agents-- both approved in UK-Prucalopride (Resolor) and more recently Linaclotide-US too- (Linzess) and stabilization of extensor rigidity- the effect never waned Also validated- course of antibiotics worsens PD rigidity-often irreversible My Conclusions ( MD with PD- not a neurologist)--ask your PMD- 1) if you are constipated-make sure you treat it effectively 2) take antibiotics only when necessary I think this is incredibly exciting!!!! **Adding Reference Links for those interested in more information: Wiley Online Quantifying rigidity of Parkinson's disease in relation to laxative treatment: a service evaluation - Augustin - 216 - British Journal of Clinical Pharmacology - Wiley Online Library PubMed Quantifying rigidity of Parkinson's disease in relation to laxative treatment: a service evaluation. - PubMed - NCBI Last edited by Chemar; 08-02-2016 at 06:57 PM. Reason: **Adding Reference Links |
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"Thanks for this!" says: | badboy99 (08-03-2016), eds195 (08-03-2016), fbollaci123 (08-03-2016), GerryW (08-03-2016), lab rat (08-03-2016), moondaughter (08-03-2016) |
08-03-2016, 08:14 AM | #2 | |||
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Recently I decided to experiment with supporting my immune system with gigartina red algae(absolutely best remedy yet for shingles outbreak common to pders)...R Rogers tells the story of a relative of his who had pd that donated his body to science- when he passed and his body went to Harvard they rejected study for pd because they deemed he had hepatitis! I wonder if they just stopped at his liver and didn't bother to check out his brain (nevermind his heart)...curiously recently I am iinspired to munch on milk thistle seeds (liver cleanse) that are growing in abundance nearby....and I feel my magnesium citrate that keeps me regulalr as important to me as mucuna! thx for this schwad
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Smooth seas do not make skillful sailors.... Nature loves courage. “The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.” ~ Nikola Tesla Last edited by moondaughter; 08-03-2016 at 08:36 AM. |
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08-03-2016, 08:21 AM | #3 | ||
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Quote:
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08-03-2016, 03:16 PM | #4 | ||
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Very Interesting.
I remember reading articles by Kelly Del Tredici & Heiko Braak discussing gut to brain links. A friend was a techinal writer for Cell Magazine, and would edit papers for publication. I was hooked as it was fascinating. It was not a popular idea in the 1980's, but they kept publishing their research and findings. Current article in Nature Magazine: Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors http://www.nature.com/nrneurol/journ....2015.197.html Oddly enough I would have never claimed to have lost my smell, but looking back for over 20 years I would "smell" things that I could visualize. Oddly enough I also would have the sense of something like roses, despite being February and none in the house. |
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"Thanks for this!" says: | schwad01 (08-03-2016) |
08-03-2016, 05:38 PM | #5 | ||
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Sometimes after I take my c/l dose, I smell a medicinal/chemical/burning, sweetish smell that can't figure out if it is real or not...kind of addicting though....I tell myself it must be brain cells disintegrating....
Eric |
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08-04-2016, 07:53 AM | #6 | ||
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I have asked Dr Dobbs whether she thinks either of the two novel agents have any additional intrinsic benefit over their laxative effect-- she said that she would just use these meds if there was still evidence of constipation after the use of bulk +/- osmotic laxatives
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