Parkinson's Disease Tulip


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Old 09-02-2016, 02:11 PM #1
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Default Lovely Antidepressants Can Cause Parkinsons

Although these drugs are generally considered to be safe by the media and amongst medical professionals and patients, a close look at the evidence suggests otherwise. Antidepressants have serious and potentially fatal adverse effects, cause potentially permanent brain damage, increase the risk of suicide and violent behavior in both children and adults, and increase the frequency and chronicity of depression. Chronic use of antidepressants also promotes dependency on drugs rather than empowering people to make positive life changes, and places a tremendous burden on healthcare systems in the U.S. and abroad.

Physiological side effects

The adverse effects of antidepressants include movement disorders, agitation, sexual dysfunction, improper bone development, improper brain development, gastrointestinal bleeding, and a variety of other lesser known problems. These are not rare events, but the most significant harm comes only after months or years of use, which leads to the false impression that antidepressants seem quite safe.

More than half of those beginning an antidepressant have one of the more common side effects (Brambilla et al. 2005).

Psychological side effects

Perhaps the best known psychological side effect of SSRIs is “amotivational syndrome”, a condition with symptoms that are clinically similar to those that develop when the frontal lobes of the brain are damaged. The syndrome is characterized by apathy, disinhibited behavior, demotivation and a personality change similar to the effects of lobotomy (Marangell et al. 2001, p.1059). All psychoactive drugs, including antidepressants, are known to blunt our emotional responses to some extent.

Clinical studies of SSRIs report that agitation is a common side effect. When Yale University’s Department of Psychiatry analyzed the admissions to their hospital’s psychiatric unit, they found that 8.1% of the patients were “found to have been admitted owing to antidepressant mania or psychosis” (Preda et al. 2001). Agitation is such a common side effect with SSRIs that the drug companies have consistently sought to hide it during clinical trials by prescribing a tranquilizer or sedative along with the antidepressant. Studies by Eli Lilly employees found that between 21% and 28% of patients taking Prozac experienced insomnia, agitation, anxiety, nervousness and restlessness, with the highest rates among people taking the highest doses (Beasley et al. 2001).

From their inception, antidepressants have been recognized as having a worrisome capacity to incite changes between episodes of depression (characterized by dysphoria, insomnia, low energy, poor concentration, reduced appetite and diminished libido) and episodes of mania (characterized by euphoria, increased activity, rapid speech, racing thoughts, diminished need for sleep, hypersexuality and diminished impulse control).

Several reports suggest that SSRIs are associated with movement disorders such as akathisia, Parkinson’s disease, dystonia (acute rigidity), dyskinesia (abnormal involuntary choreic movements) and tardive dyskiniesia (Gerber & Lynd 1998).

These movement disorders are serious enough on their own. However, what is even more alarming is the potential for akathisia to induce aggression and suicide. Akathisia, a condition of inner restlessness or severe agitation, is the most commonly occurring movement disorder associated with psychoactive drug use. Akathisia-related violence receives specific attention in the Diagnostic and Statistical Manual of Mental Disorders (DSM). Akathisia has been shown to increase violent behavior and suicide, and antidepressants are known to cause akathisia.

Suicide

After years of foot-dragging and thousands of excess suicides, the FDA finally admitted that “two to three children out of every hundred” could be expected to develop suicidal thoughts or actions as a result of antidepressant therapy (Harris 2004). The risk of suicide events for children receiving SSRIs has been three times higher than placebo. (Healy 2005). Amazingly, no bans or restrictions have been placed on their use in children in the U.S.

While the increased risk of suicide in children has become better known, most people are unaware that a similar risk exists for adults. When adult antidepressant trials were re-analyzed to compensate for erroneous methodologies, SSRIs have consistently revealed a risk of suicide (completed or attempted) that is two to four times higher than placebo (Healy 2005).

Turning short-term suffering into long-term misery

A growing body of research supports the hypothesis that antidepressants worsen the chronicity, if not severity, of depressive features in many subjects. Antidepressant therapy is often associated with the poorest outcomes. In a large, retrospective study in the Netherlands of more than 12,000 patients, antidepressant exposure was associated with the worst long term results. 72-79% of the patients who relapsed received antidepressants during their initial episode of depression. In contrast, only one of the patients who did not relapse received no antidepressants during or following the initial episode. (Weel-Baumgarten 2000)

Longitudinal (long-term) follow-up stuides show very poor outcomes for people treated for depression in both hospital and outpatient settings, and the overall prevalence of depression is rising despite increased use of antidepressants (Moncrieff & Kirsch 2006).

Epidemiological observations have long held that most episodes of depression end after three to six months. However, almost half of all Americans treated with antidepressants have remained on medication for more than a year (Antonuccio et al. 2004).

Long-term effects of antidepressants

Antidepressants have been shown to produce long-term, and in some cases, irreversible chemical and structural changes to the body and brain.

The administration of Prozac and Paxil raises cortisol levels in human subjects (Jackson 2005, p.90). Given the fact that elevated cortisol levels are associated with depression, weight gain, immune dysfunction, and memory problems, the possibility that antidepressants may contribute to prolonged elevations in cortisol is alarming to say the least.

In a study designed to investigate the anatomic effects of serotonergenic compounds, researchers at Thomas Jefferson University found that high-dose, short-term exposure to SSRIs in rats was sufficient to produce swelling and kinking in the serotonin nerve fibers (Kalia 2000). Research performed by a different group of investigators showed that antidepressants can kill neurons and cause structural changes similar to those observed in Parkinson’s in rodents.

I want to emphasize that what I’ve covered here is only the beginning of the story when it comes to the adverse effects of antidepressants. There are volumes of published research and many books which present this information with much more detail. I recommend Peter Breggin’s landmark “Brain Disabling Treatments in Psychiatry” and Grace Jackson’s “Rethinking Psychiatric Drugs” as resources if you are interested in pursuing this further.


repeat......Several reports suggest that SSRIs are associated with movement disorders such as akathisia, Parkinson’s disease, dystonia (acute rigidity), dyskinesia (abnormal involuntary choreic movements) and tardive dyskiniesia (Gerber & Lynd 1998).

REFS:

The dark side of antidepressants
⏲on July 15, 2008 👤by Chris Kresser
Pharmacopsychiatry. 2005 Mar;38(2):69-77.
Side-effect profile of fluoxetine in comparison with other SSRIs, tricyclic and newer antidepressants: a meta-analysis of clinical trial data.
Brambilla P1, Cipriani A, Hotopf M, Barbui C

Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15): 5582–5587.
Published online 2005 Apr 4. doi: 10.1073/pnas.0501509102
Neuroscience

Mark S. Ansorge1,2,3,
Mingming Zhou2,3,
Alena Lira2,3,
René Hen2,4,
Jay A. Gingrich2

Science 29 Oct 2004:
Vol. 306, Issue 5697, pp. 879-881
DOI: 10.1126/science.1101678

The American Psychiatric Publishing Textbook of Clinical Psychiatry, Volume 1

J Clin Psychiatry. 2001 Jan;62(1):30-3.

Antidepressant-associated mania and psychosis resulting in psychiatric admissions.

Preda A1, MacLean RW, Mazure CM, Bowers MB Jr.

J Clin Psychopharmacol. 1991 Jun;11(3):166-74.

High-dose fluoxetine: efficacy and activating-sedating effects in agitated and retarded depression.

Beasley CM Jr1, Sayler ME, Bosomworth JC, Wernicke JF.

Selective serotonin-reuptake inhibitor-induced movement disorders.

Gerber PE1, Lynd LD

Efficacy of antidepressants in adults
BMJ 2005; 331 doi: Efficacy of antidepressants in adults | The BMJ (Published 14 July 2005)

Int Rev Psychiatry. 2005 Jun;17(3):163-72.

Antidepressant drug use & the risk of suicide.

Healy D1, Aldred G.
Cite this as: BMJ 2005;331:155

ET AL ET AL ET AL......in perpetuity......

now how do antidepressants sound? to most americans I know.....give me some!

one of the first questions my mvmnt spec asked was to list antidepressants I had been exposed to.....he went down a list of suspected contributors/instigators of pd...Geodon....Lithium....on and on.....


Cheers!

BP
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Old 09-02-2016, 04:00 PM #2
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Hello,
There can be legal issues with full copy/paste from sites, due to copyright laws..

You will find the copyright logo/icon information at the bottom of most websites.
like this © 2016 Chris Kresser. All Rights Reserved.

Ours is this Copyright ©2000 - 2016, Jelsoft Enterprises Ltd.

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Old 09-02-2016, 04:50 PM #3
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link.....The dark side of antidepressants

and the article was not quite cited entirely i left out some stuff........and interjected a couple things but credit and cites are listed at the bottom and here is the link.......


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