Parkinson's Disease Tulip


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Old 09-18-2016, 04:36 AM #1
Sandgroper Sandgroper is offline
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Yes, the Herald Sun newspaper article is correct. This is Phase 1 and 2a (safety, tolerability and efficacy) of a world-first trial injecting parthenogenetic stem cells into the brains of 12 humans. Phase 1 and 2a is being conducted over a 12 month + period, the first candidate underwent surgery in July 2016 and the second is now being prepped for surgery Sept/Oct. The trial is being conducted at the Royal Melbourne Hospital under the leadership of neurologist Dr Andrew Evans and neurosurgeon Dr Girish Nair. Phase 3 and 4 double-blind placebo is expected to follow if the outcome of Phase 1 and 2a is successful.
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Old 09-18-2016, 01:31 PM #2
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Originally Posted by Sandgroper View Post
Yes, the Herald Sun newspaper article is correct. This is Phase 1 and 2a (safety, tolerability and efficacy) of a world-first trial injecting parthenogenetic stem cells into the brains of 12 humans. Phase 1 and 2a is being conducted over a 12 month + period, the first candidate underwent surgery in July 2016 and the second is now being prepped for surgery Sept/Oct. The trial is being conducted at the Royal Melbourne Hospital under the leadership of neurologist Dr Andrew Evans and neurosurgeon Dr Girish Nair. Phase 3 and 4 double-blind placebo is expected to follow if the outcome of Phase 1 and 2a is successful.
Just wondering, how would they conduct a double blind placebo controlled clinical trial that involves deep brain surgery?
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Old 09-18-2016, 01:48 PM #3
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Just wondering, how would they conduct a double blind placebo controlled clinical trial that involves deep brain surgery?
I don't know how DBS got approved without a placebo but it sure as heck works!
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Old 09-27-2016, 09:32 PM #4
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At the final event in Portland several of the main speakers spoke passionately about how claims made in the name of stem cell research are putting the field behind by years.
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Old 05-01-2017, 09:20 PM #5
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Default Another milestone reached (stem cell transplantation)

The Melbourne, Australia project rolls on. The 4th patient (i.e. the last one in the first cohort) has received his/her 30 million stem cells.

The next patient (i.e. the first one in the second cohort of 4 patients) is scheduled to receive 50 million stem cells.

Each of the 4 patients in the third cohort are scheduled to receive 70 million stem cells.

International Stem Cell Corporation Completes First Cohort In Parkinson's Disease Clinical Trial Other OTC:ISCO
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Old 04-18-2018, 06:43 AM #6
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Default Another project update

The Melbourne, Australia project has rolled on some more:
- All 4 patients in the first cohort have received their 30 million stem cells.
- The first 2 patients in the second cohort have received their 50 million stem cells.
- Each of the 4 patients in the third cohort are scheduled to receive 70 million stem cells.

#AAN218 - Neural Stem Cells Show Promise as Parkinson’s Therapy
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Old 07-29-2018, 07:25 AM #7
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This recent paper from International Stem Cell Corporation (ISCO) contains a lot of background information on the technology used in the Melbourne project.

https://www.liebertpub.com/doi/10.1089/scd.2018.0001
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