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12-15-2016, 10:32 AM | #1 | ||
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Finnish re-search-ers cor-rect Par-kin-son's mo-tor symp-toms in mice | EurekAlert! Science News
Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector–Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain | Journal of Neuroscience |
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12-16-2016, 12:48 PM | #2 | ||
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Medical News Today report [1].
"blocking an enzyme called prolyl oligopeptidase clears the mice's brains of an accumulated protein that is the hallmark of [PD], halts further brain damage, and corrects movement impairment." Some botanicals inhibit prolyl oligopeptidase, for instance [2]: - baicalin; - berberine. In a 2012 post to this forum, wxxu mentions taking baicalin in Chinese Skullcap. [3]. I'd be grateful for an update, please, wxxu. Reference: [1] Parkinson's disease: Blocking brain enzyme corrects motor symptoms in mice - Medical News Today [2] Prolyl endopeptidase - Wikipedia [3] Powerful Class of Antioxidants May Be Potent Parkinson's Treatment John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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"Thanks for this!" says: | lab rat (12-20-2016) |
12-16-2016, 11:02 PM | #3 | ||
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Hi John,
That was a couple years ago. I tried one bottle (90 Cap, 400 mg x 90) and stopped because it made me sleep way too much. In recent years I have tried Berberine (500 mg/day), and it has made me feel better overall. My blood sugar, fat and BP are completely normal after two months of taking Berberine. I may pick up baicalin again as it is very popular in China as one of the most safe and effective Chinese herbal antioxidants. It has been using for a long time for treating serious acute liver infection and many other diseases in injections... Will |
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