Finnish re-search-ers cor-rect Par-kin-son's mo-tor symp-toms in mice | EurekAlert! Science News

Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector–Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain | Journal of Neuroscience

Medical News Today report [1].

"blocking an enzyme called prolyl oligopeptidase clears the mice's brains of an accumulated protein that is the hallmark of [PD], halts further brain damage, and corrects movement impairment."

Some botanicals inhibit prolyl oligopeptidase, for instance [2]:
- baicalin;
- berberine.

In a 2012 post to this forum, wxxu mentions taking baicalin in Chinese Skullcap. [3]. I'd be grateful for an update, please, wxxu.

Reference:

[1] Parkinson's disease: Blocking brain enzyme corrects motor symptoms in mice - Medical News Today

[2] Prolyl endopeptidase - Wikipedia

[3] Powerful Class of Antioxidants May Be Potent Parkinson's Treatment

John

Hi John,

That was a couple years ago. I tried one bottle (90 Cap, 400 mg x 90) and stopped because it made me sleep way too much. In recent years I have tried Berberine (500 mg/day), and it has made me feel better overall. My blood sugar, fat and BP are completely normal after two months of taking Berberine. I may pick up baicalin again as it is very popular in China as one of the most safe and effective Chinese herbal antioxidants. It has been using for a long time for treating serious acute liver infection and many other diseases in injections... Will