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01-04-2017, 11:42 AM | #1 | |||
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01-04-2017, 11:38 PM | #2 | |||
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Grand Magnate
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That is a very interesting paper.
It supports studies which show that some metal ions, including Mn(II), can interact with α-synuclein leading, in model systems, to increased neurotoxicity Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease - Metallomics (RSC Publishing) DOI:1 .1 39/C4MT 339J.
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03-13-2017, 10:41 PM | #3 | ||
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The paper by Racette et al. [1] shows the effect of manganese, as measured by UPDRS score, in a population of welders. The interesting point is that the workers were not (as yet) diagnosed with parkinsonism. Multiple follow-ups show a slow progression over many years but not, for most at least, being severe enough to get medical attention.
Reference: [1] "Dose-dependent progression of parkinsonism in manganese-exposed welders" Brad A. Racette, MD, Susan Searles Nielsen, PhD, Susan R. Criswell, MD, MSCI, Lianne Sheppard, PhD, Noah Seixas, PhD, Mark N. Warden, MS and Harvey Checkoway, PhD Neurology, Dec 2016. Dose-dependent progression of parkinsonism in manganese-exposed welders John
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Born 1955. Diagnosed PD 2005. Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg |
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