Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 03-10-2017, 10:01 PM #1
Tupelo3 Tupelo3 is offline
Member
 
Join Date: Mar 2013
Location: New Jersey
Posts: 832
10 yr Member
Tupelo3 Tupelo3 is offline
Member
 
Join Date: Mar 2013
Location: New Jersey
Posts: 832
10 yr Member
Default Inhibikase begins research on IkT-148009 - a powerful new c-Abl inhibitor

Inhibikase Therapeutics, with funding from The Michael J. Fox Foundation, began pre-IND studies of the company's novel Abelson tyrosine kinase (c-Abl) inhibitors, IkT-148009, as a potential Parkinson's disease (PD) treatment. Inhibikase is also one of the three entities studying Nilotinib as a PD treatment.

IkT-148009, is a highly potent, first-in-class, small-molecule drug designed and engineered as a chronically administered, once-daily oral medication that targets an underlying biological mechanism that leads to Parkinson's disease, with the goal of reversing disease progression. IkT-148009 is designed to block the activation of Abl kinase, a clinically validated drug target, to prevent and/or reverse the loss of dopamine-secreting neurons in the brain by restoring neuroprotective mechanisms. IkT-148009 is believed to be 50 times more brain penetrable than Nilotinib due to the small size of the molecule.

Inhibikase Wins $433, MJFF Grant to Study c-Abl Inhibitors as Parkinson's Treatment | GEN
Tupelo3 is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
eds195 (03-10-2017), jeffreyn (03-10-2017), lab rat (03-11-2017), RLSmi (03-11-2017), soccertese (03-11-2017)

advertisement
Old 03-11-2017, 05:02 AM #2
jeffreyn jeffreyn is offline
Member
 
Join Date: Apr 2016
Location: Australia
Posts: 352
8 yr Member
jeffreyn jeffreyn is offline
Member
 
Join Date: Apr 2016
Location: Australia
Posts: 352
8 yr Member
Default Some more c-Abl related news

Todd Sherer (MJFF) gave an update on c-Abl related matters a couple of days ago. He writes about the upcoming MJFF el al. trial, and also about the work of Inhibikase, and the work of Georgetown University:

Uncovering the Promise of c-Abl as a Therapeutic Target: Testing Available Treatments and Supporting New Therapies | Parkinson's Disease

Something else which may be of interest is the MJFF grant record for the current phase (i.e. the planning phase) of the MJFF et al. nilotinib trial:

Planning Phase for a Phase IIa Study of Nilotinib in People with Parkinson's Disease | Parkinson's Disease

and here is the MJFF grant record for the Inhibikase project:

Small Molecule Inhibitors of C-Abl for Parkinson's Disease Modification | Parkinson's Disease
jeffreyn is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
anagirl (03-11-2017), eds195 (03-11-2017), lab rat (03-11-2017), RLSmi (03-11-2017), soccertese (03-11-2017), Tupelo3 (03-11-2017)
Old 03-11-2017, 09:55 AM #3
Tupelo3 Tupelo3 is offline
Member
 
Join Date: Mar 2013
Location: New Jersey
Posts: 832
10 yr Member
Tupelo3 Tupelo3 is offline
Member
 
Join Date: Mar 2013
Location: New Jersey
Posts: 832
10 yr Member
Default

[QUOTE=jeffreyn;1238496]Todd Sherer (MJFF) gave an update on c-Abl related matters a couple of days ago. He writes about the upcoming MJFF el al. trial, and also about the work of Inhibikase, and the work of Georgetown University:

Uncovering the Promise of c-Abl as a Therapeutic Target: Testing Available Treatments and Supporting New Therapies | Parkinson's Disease

Something else which may be of interest is the MJFF grant record for the current phase (i.e. the planning phase) of the MJFF et al. nilotinib trial:


Thanks Jeffrey. The only update I would have on the above is that the MJFF et al trial is more likely to begin around Sept. Originally, the hope was mid-year (July). I also wouldn't be surprised if it pushes back a little more from there. But, it will happen, which is what matters.
Tupelo3 is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
anagirl (03-11-2017), eds195 (03-11-2017), jeffreyn (03-11-2017), lab rat (03-11-2017), RLSmi (03-11-2017), soccertese (03-11-2017)
Reply

Tags
disease, ikt-148009, inhibikase, kinase, parkinsons


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Pain-RX - Cox 2 Inhibitor caroline2 Vitamins, Nutrients, Herbs and Supplements 3 04-20-2019 09:45 PM
Ace inhibitor? Ccm47 Reflex Sympathetic Dystrophy (RSD and CRPS) 1 05-18-2013 09:23 AM
Powerful Fox Ad Puts Focus on Embryonic Stem Cell Research Howardh Parkinson's Disease 6 10-28-2006 06:54 PM


All times are GMT -5. The time now is 05:52 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.