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02-07-2017, 09:53 PM
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Grand Magnate
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A recent report shows that squalamine (made by a kind of shark) can block α-synuclein aggregation as well as its toxicity in a human cell line and in a worm model.
http://www.pnas.org/content/114/6/E1009.full.pdf
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| "Thanks for this!" says: | toyL (07-13-2018) |
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02-07-2017, 10:57 PM
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Member
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Hi kiwi33,
A thread on this topic was started last month (same research paper): Steroid [squalamine] Attacks PD-Related Toxin [a-syn clumps] in Animal Model [worm] |
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02-08-2017, 04:17 AM
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Grand Magnate
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Sorry jefferyn.
The paper in its final form is in the latest issue of PNAS (Volume 114(6), 7 February). I got my regular automatic email advisory of PNAS issues this morning and it did not occur to me to check if somebody might have noticed it in pre-publication form.
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| "Thanks for this!" says: | jeffreyn (02-08-2017) |
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02-08-2017, 08:48 PM
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Member
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No worries, kiwi33.
The other thread didn't generate any discussion, but there was some discussion in a similar thread elsewhere. Summary of the discussion: - may be more work needed regarding possible uncertainty in degree of penetration of the blood-brain barrier; - available supplement (Squalamax) contains a very small amount of squalamine; - overall: potentially important development but still some way to go. |
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06-30-2018, 07:07 AM
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#5 | ||
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From the SoPD blog, an update on Squalamine.
Squalamine begets Trodusquemine | The Science of Parkinson's |
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| "Thanks for this!" says: | lab rat (07-01-2018) |
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07-04-2018, 11:33 AM
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#6 | ||
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Since it will take forever to clinical trial these, anyone who wants to take the risk and self dose maybe can find a source to buy trodusquemine. Somewhere in these articles it mentions that squalamine does not cross the b/b.
Squalamine and Squalamine Supplement trodusquemine price - Google Search |
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